Jakura 5 mg (Tofacitinib) – 60 Tablets

Introduction to Jakura 5 mg

Jakura 5 mg is a prescription oral medicine manufactured by Hetero Healthcare Pvt Ltd, designed to manage complex autoimmune conditions. Classified under arthritis medicine, Jakura tablets contain the active ingredient Tofacitinib, a targeted small molecule drug.

Jakura is widely prescribed for patients suffering from rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and ankylosing spondylitis. By addressing chronic inflammation at the root level, it helps restore mobility, reduce pain, and improve overall quality of life.

 

What is Tofacitinib (Jakura)?

Tofacitinib is the generic name for Jakura. It belongs to a class of drugs called Janus kinase (JAK) inhibitors, specifically blocking JAK1 and JAK3 enzymes to regulate the JAK-STAT signaling pathway.

Jakura is a generic version of the well-known brand Xeljanz, approved by the FDA and EMA. Other generic alternatives include Tofacent, Tofacinix, and Tofaxen, but Jakura 5 mg is favored for its affordability and trusted manufacturing standards.

 

Mechanism of Action

Jakura 5 mg works by blocking JAK enzymes responsible for triggering immune system overactivity.

• JAK-STAT signaling pathway: This pathway is essential in transmitting signals for inflammation.
• JAK1 & JAK3 inhibition: Jakura directly inhibits these enzymes at their ATP-binding sites, preventing excessive immune responses.
• Immunomodulatory therapy: Unlike steroids, Jakura is a small molecule oral targeted therapy, offering precision in controlling inflammation.
• Comparison to Biologic DMARDs: While biologics require injections, Jakura offers convenience in oral form with rapid systemic effects.

This unique mechanism makes Jakura highly effective in controlling autoimmune inflammatory disorders.

 

Approved Indications of Jakura 5 mg

Jakura 5 mg is approved for the treatment of several autoimmune diseases:

• Rheumatoid Arthritis (RA): Effective in moderate to severe RA, especially for patients with methotrexate inadequate response.
• Psoriatic Arthritis (PsA): Reduces joint pain, swelling, and skin symptoms in PsA.
• Ulcerative Colitis (UC): Particularly useful in steroid-resistant ulcerative colitis, reducing bowel inflammation.
• Ankylosing Spondylitis (AS): Improves spinal mobility and reduces stiffness.
• Chronic Inflammatory Joint Diseases: Helps prevent long-term joint damage.
• Systemic Autoimmune Diseases: Used in immune-driven chronic conditions where biologics may fail.

By targeting the root inflammatory pathways, Jakura offers consistent relief for patients.

 

Dosage & Administration

The recommended dose of Jakura 5 mg tablets is:

• Rheumatoid Arthritis / Psoriatic Arthritis: 5 mg twice daily
• Ulcerative Colitis: Initially higher doses may be prescribed, followed by 5 mg twice daily maintenance
• Ankylosing Spondylitis: 5 mg twice daily

Dose Adjustments

• Jakura 10 mg: May be used in specific UC cases, under doctor supervision.
• Renal impairment / Liver disease: Dose adjustments are required to prevent toxicity.

Jakura is taken orally with or without food. Patients should not self-adjust dosage without medical advice.

 

Clinical Effectiveness & Benefits

Clinical studies demonstrate that Jakura significantly improves joint health, mobility, and quality of life.

• Reduction of Inflammation: Jakura directly targets immune overactivity.
• Long-Term Treatment Adherence: As an oral small molecule drug, it’s easier for patients to continue compared to injectable biologics.
• Improved Quality of Life: Patients report reduced fatigue, less morning stiffness, and better functional outcomes.

This makes Jakura a reliable choice for chronic management of autoimmune conditions.

 

Side Effects & Safety Profile

While effective, Jakura 5 mg carries important safety considerations.

Common Side Effects:

• Headache, diarrhea, nausea
• Elevated cholesterol levels
• Minor infections (cough, cold)

Serious Risks:

• Risk of Serious Infections: Patients should undergo tuberculosis screening before treatment.
• Opportunistic Infections: Higher risk of herpes zoster, fungal infections.
• Malignancy Risk: Slightly increased risk of lymphoma and skin cancers.
• Blood Clot Risk: FDA issued a black box warning for DVT and pulmonary embolism.
• Organ Effects: Requires monitoring in liver disease and kidney disease patients.

Monitoring:

• Routine blood tests (CBC, liver function, lipid profile)
• Pregnancy & Breastfeeding: Not recommended without specialist approval.

 

Drug Interactions

Jakura interacts with several drugs:

• Immunosuppressants: Combined use increases infection risks.
• Strong CYP3A4 Inhibitors (ketoconazole, clarithromycin): Increase drug concentration.
• Strong CYP3A4 Inducers (rifampin, carbamazepine): Reduce drug effectiveness.

Doctors carefully evaluate patient medications before prescribing Jakura.

 

Regulatory Approvals

• FDA Approval: Tofacitinib received FDA approval in 2012 for RA, later expanded to PsA and UC.
• EMA Approval: Approved in Europe for RA, PsA, and UC.
• Global Reach: Through pharmaceutical exports from India, Jakura has become an affordable arthritis medicine in multiple countries.

 

Comparison: Jakura vs Other Brands

Brand Name	Manufacturer	Dosage	Key Feature	Price Range
Jakura 5 mg	Hetero Healthcare Pvt Ltd.	5 mg	Affordable Generic option	Low
Xeljanz	Pfizer	5 mg	Original FDA-approved brand	High
Tofacent	Beacon Pharma	5 mg	Widely used in Worldwide	Moderate
Tofacinix	Beacon Pharma	5 mg	Generic Alternative	Moderate
Tofaxen	Everest Pharma	5 mg	Cost-effective option	Moderate

Jakura stands out for its affordability and reliability, especially in international markets.

 

Cost & Availability

In Unit Pharmacy the cost of Jakura 5 Mg is $ 200 USD. The cost of Jakura 5 mg varies by region:

• Europe: Higher due to brand pricing, patients often seek generics.
• Asia: Significantly more affordable as a generic.

Patients can buy Jakura from online pharmacies Unit Pharmacy with worldwide delivery, making it accessible beyond local pharmacies.

 

Patient-Centric Perspective

Patients using Jakura 5 mg report:

• Better disease control compared to methotrexate alone
• Long-term adherence thanks to oral formulation
• Improved quality of life with reduced stiffness and pain

For patients who fail on biologics like adalimumab or etanercept, Jakura offers an effective alternative arthritis therapy.

 

Precautions & Monitoring Before Use

Before starting Jakura, doctors recommend:

• Tuberculosis screening
• Routine blood tests (CBC, liver, lipid profile)
• Avoiding pregnancy & breastfeeding during therapy
• Special caution in patients with liver disease, kidney disease, or history of blood clots

 

Expert Insights

Specialists highlight Jakura’s role as a game-changer in autoimmune disease management. By combining E-E-A-T principles (expertise, evidence, safety monitoring), it strengthens trust among healthcare professionals and patients.

Jakura bridges the gap between traditional biologics and modern oral targeted therapies, reshaping the treatment landscape for chronic autoimmune inflammatory disorders.

 

Conclusion

Jakura 5 mg (Tofacitinib) is an advanced oral targeted therapy for autoimmune diseases such as rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and ankylosing spondylitis. By blocking JAK1 and JAK3 enzymes in the JAK-STAT pathway, it reduces inflammation, controls symptoms, and helps patients regain mobility and improve quality of life.

 

Manufactured by Hetero Healthcare Pvt Ltd, Jakura is a trusted and affordable arthritis medicine, offering a safe alternative to costly brands like Xeljanz. With FDA and EMA approval for its active ingredient Tofacitinib, it is widely recommended for patients who did not respond to methotrexate or biologics.

 

Though patients must be monitored for infections, blood clots, liver and kidney disease, regular blood tests help ensure safe long-term use. Thanks to strong pharmaceutical exports from India, Jakura 5 mg is accessible worldwide through local and online pharmacies.

 

In short, Jakura is a powerful Janus kinase inhibitor, providing effective, safe, and affordable treatment for chronic autoimmune inflammatory disorders helping patients lead a healthier, pain-free life.