Osimertinib, also known by the brand name Tagrisso, is an oral medication used to treat specific types of non-small-cell lung cancer (NSCLC). It is a third-generation EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor), developed to overcome resistance to previous therapies.If you’re looking to buy Osimertinib online, it’s essential to understand its function, dosage, safety, and cost. Mainly you need to complete guidance.
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Osimertinib (Tagrisso) was developed by AstraZeneca to target EGFR T790M mutations in patients who developed resistance to earlier EGFR inhibitors. The need for a medicine with better results and fewer side effects pushed this development forward. With its oral administration and precision-targeting capabilities, Osimertinib oral therapy marked a breakthrough in targeted cancer treatment.
Osimertinib is prescribed in the first place for patients with non-small-cell lung cancer who test positive for specific EGFR mutations. It’s usually given when the cancer has spread (metastasized) or has not responded well to earlier EGFR therapies. It may also be used after surgery in early-stage NSCLC to prevent recurrence. You may often hear questions like “What is Osimertinib?” The answer lies in its precision targeting of genetic mutations in cancer cells.
Understanding the Osimertinib mechanism of action is key. This drug works by blocking mutated EGFR proteins, which are responsible for the uncontrolled growth of cancer cells in some lung cancer patients. This targeted inhibition stops or slows the cancer’s growth while limiting harm to healthy cells.
If you’re wondering how osimertinib works, think of it as a lock-and-key mechanism where it binds to the mutated receptor and shuts down the signaling pathway that tells the cancer to grow.
Osimertinib (Tagrisso) comes in oral tablet form and is usually taken once a day. It can be taken with or without food. The Osimertinib dose most commonly prescribed is 80 mg daily. Patients should swallow the tablet whole and not crush or split it.
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Besides NSCLC, Osimertinib is under research for use in other EGFR mutation-related cancers, though these are not currently approved indications. However, in some cases, doctors may prescribe it off-label when other treatment options fail.
Before starting Osimertinib (Tagrisso): tell your doctor about all health conditions, medications, or pregnancy plans, avoid grapefruit, use birth control, stay alert for side effects, and follow all medical advice for safe and effective use.
You should undergo genetic testing to confirm EGFR mutations, especially T790M, as Osimertinib is only effective for specific mutations. Discuss any history of interstitial lung disease, cardiac conditions, or eye disorders with your healthcare provider.
There are no strict dietary restrictions, but you should avoid grapefruit or grapefruit juice as it may interfere with Osimertinib’s metabolism. Stay hydrated and follow a balanced diet to support your overall health during treatment.
Osimertinib, marketed as Tagrisso, received its initial accelerated approval from the U.S. Food and Drug Administration (FDA) on November 13, 2015, for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) harboring the EGFR T790M mutation, following progression on or after EGFR TKI therapy. This approval was based on an overall response rate of 59% observed in clinical trials.
Subsequently, on March 30, 2017, the FDA granted regular approval to Osimertinib for the same indication, supported by data from the AURA3 trial, which demonstrated a significant improvement in progression-free survival compared to chemotherapy.
Over the years, the osimertinib FDA expanded indications:
These approvals underscore Osimertinib’s role as a cornerstone in the management of EGFR mutation-positive NSCLC across various stages of the disease.
The core Osimertinib mechanism of action lies in its ability to irreversibly bind to mutated forms of the EGFR protein, especially T790M, which is resistant to first- and second-generation EGFR inhibitors. This binding blocks the signaling needed for cancer cell survival and division.
Side effects that you should report to your care team as soon as possible because in this type of side effects are injurious:
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. Knowing the side effects of Osimertinib helps patients stay prepared and proactive in managing their health. You may report side effects to the FDA at 1-800-FDA-1088.
Osimertinib, marketed as Tagrisso, is prescribed for various stages of non-small cell lung cancer (NSCLC) with specific EGFR mutations. The standard dosage is 80 mg taken orally once daily, with or without food. Treatment duration and administration may vary based on the specific indication and patient response.
Recommended Dosage by Indication
|
Indication |
Dosage | Duration |
| Adjuvant treatment of EGFR mutation-positive NSCLC | 80 mg orally once daily | Up to 3 years or until disease recurrence or unacceptable toxicity |
| Locally advanced, unresectable (Stage III) EGFR mutation-positive NSCLC | 80 mg orally once daily | Until disease progression or unacceptable toxicity |
| First-line treatment of EGFR mutation-positive metastatic NSCLC | 80 mg orally once daily | Until disease progression or unacceptable toxicity |
| First-line treatment of EGFR mutation-positive locally advanced/metastatic NSCLC in combination with chemotherapy | 80 mg orally once daily | Until disease progression or unacceptable toxicity; refer to chemotherapy dosing guidelines |
| Previously treated EGFR T790M mutation-positive metastatic NSCLC | 80 mg orally once daily |
Until disease progression or unacceptable toxicity |
Always consult with a healthcare professional before making any changes to the medication regimen.
If you miss a dose of Osimertinib (Tagrisso), take it as soon as you remember—unless it’s less than 12 hours until your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up, as this may increase the risk of side effects. Missing occasional doses may reduce treatment effectiveness, so it’s essential to stay consistent. Use reminders or medication tracking tools to help maintain daily dosing. Always consult your healthcare provider if you frequently forget doses or are unsure what to do.
Osimertinib is produced by several reputable pharmaceutical companies worldwide to ensure quality, safety, and affordability for patients. The original brand, Tagrisso, is manufactured by AstraZeneca. However, cost-effective generic versions are now available from reliable manufacturers such as Beacon Pharmaceuticals (Tagrix), Everest Pharma (Osimert), and Incepta Pharmaceuticals (Osicent). These generics maintain high quality and are widely used in countries like Australia, Usa, Saudi Arabia and other regions.
Patients looking to buy Osimertinib online can trust these global manufacturers for authentic and effective treatment options. Always choose licensed sources like Unit Pharmacy to ensure safe access to genuine medicines.
Osimertinib brand options vary across countries. The most recognized brand is Tagrisso, but there are high-quality generic options available, such as:
|
Brand Name |
Manufacturer |
| Tagrix 80 mg (Osimertinib)- 30 Tablets | Beacon Pharmaceuticals |
| Osimert 80 Mg (Osimertinib) – 30 Tablets | Everest Pharma |
| Osicent 80 Mg (Osimertinib) – 30 Tablets |
Incepta Pharmaceuticals |
You can buy Osimertinib generics through our pharmacy to save on costs. We also ship worldwide for those searching “Osimertinib near me”.
The Osimertinib price can vary significantly by brand and country. Original Tagrisso can be expensive, often costing thousands of dollars per month. Generic versions offer a more affordable Osimertinib solution.
|
Product |
Strength | Average Monthly Cost (USD) |
| Tagrisso | 80 mg | $12,000 – $15,000 |
| Tagrix | 80 mg | $300 |
| Osimert
Osicent |
80 mg
80 mg |
$75 $110 |
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Osimertinib (Tagrisso) is an oral EGFR tyrosine kinase inhibitor indicated for the treatment of non-small cell lung cancer (NSCLC) in patients with specific EGFR mutations. Its FDA-approved uses include:
Adjuvant therapy: Post-surgical treatment for patients with NSCLC harboring EGFR exon 19 deletions or exon 21 L858R mutations.
Locally advanced, unresectable (Stage III) NSCLC: For patients whose disease has not progressed after platinum-based chemoradiation therapy, with EGFR exon 19 deletions or exon 21 L858R mutations.
First-line treatment of metastatic NSCLC: In patients with EGFR exon 19 deletions or exon 21 L858R mutations.
First-line treatment in combination with chemotherapy: For locally advanced or metastatic NSCLC with EGFR exon 19 deletions or exon 21 L858R mutations.
Treatment of metastatic EGFR T790M mutation-positive NSCLC: In patients who have progressed on or after EGFR TKI therapy.
These indications underscore Osimertinib’s role in managing EGFR mutation-positive NSCLC across various stages of the disease.
Osimertinib (Tagrisso) has transformed the treatment landscape for lung cancer patients with EGFR mutations. It offers targeted therapy with high efficacy and manageable side effects. Whether you’re a caregiver or patient seeking to buy Osimertinib, understanding its cost, side effects, dosage, and mechanism is crucial.
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