Azarest 300 MG (Azacitidine cost) – 14 TABLETS

Azarest 300 MG (Azacitidine cost)

Product Name: Azarest 300 MG
Generic Name: Azacitidine
Form: Tablet
Pack Size: 14 tablets per pot
Strength: 300 mg
Registration: Export Only

Maintaining Remission

After achieving their first complete remission (CR) or partial remission with some blood count issues (CRi) following initial intensive chemotherapy, Azarest 300 MG (Azacitidine cost) is administered to help prevent the cancer from recurring. This maintenance therapy plays a crucial role in extending the period of remission and reducing the likelihood of relapse.

For Those Who Can’t Handle Intensive Therapy

Some patients can’t undergo aggressive treatments due to their age, other health issues, or overall condition. For these patients, Azarest provides an effective alternative to more intensive therapies. 

Azacitidine Mechanism of Action

When taken orally, about 11% of Azacitidine is absorbed into the bloodstream compared to the subcutaneous route. It reaches peak blood levels approximately one hour after ingestion.

Dosage and Administration

• Do not substitute Azacitidine tablets for intravenous or subcutaneous forms due to different uses and dosages.
• Take Azarest 300 MG orally once daily for the first 14 days of a 28-day cycle, with or without food.
• Continue treatment unless severe side effects occur or the condition worsens.
• Take anti-nausea medication 30 minutes before each dose during the first two cycles. If no nausea or vomiting occurs, the anti-nausea medication can be discontinued in later cycles.
• Do not start a new cycle if the absolute neutrophil count (ANC) is below 0.5 Gi/L. Wait until the ANC is 0.5 Gi/L or higher to begin the cycle.

Instructions

• Do not split, crush, or chew the tablets.
• Take the dose at the same time each day.
• If a dose is missed, take it as soon as possible on the same day. Resume the regular schedule the next day.
• Do not take two doses on the same day. If vomiting occurs after taking a dose, do not take another dose that day. Continue with the next dose as scheduled.

Azacitidine Side Effects

Clinical Trials:

Serious Reactions 

During the treatment 15% of the patients experienced febrile neutropenia and pneumonia. One death report submitted a form of sepsis. 

Discontinuation

Some common side effects are nausea, diarrhea, and vomiting. 8% of patients experience this during treatments. 

Interruptions

 35% paused treatment mainly due to neutropenia, thrombocytopenia, and nausea.

Dose Reductions

After starting the treatments, 14% of patients have to reduce their dose because of side effects.The side effects are  neutropenia, diarrhea, and thrombocytopenia.

Common Side Effects

 Nausea, vomiting, diarrhea, fatigue, constipation, pneumonia, abdominal pain, joint pain, decreased appetite, febrile neutropenia, dizziness, and limb pain affected over 10% of patients.

Azacitidine Side Effects in Elderly

Elderly patients taking azacitidine may experience several side effects:

Bone Marrow Suppression

It is a common side effect for the elders who are treated  with azacitidine. It can be the reason for lower counts of red blood cells, white blood cells, and also platelets. Patients experience this very soon after starting the treatments. And resolved before starting the next cycle of the treatments. Some patients might reduce the dose. 

Injection Site Reactions 

When patients take injection some of them experience mild redness on the skin, where injection is given. 

Gastrointestinal Issues

After starting the treatment nausea and constipation is a common side effect. If any patients experience this, they can take anti- nausea medicine. 

 Fever

Fever is a common side effect. Patients might experience fever for at least 5 to 7 days. It      is recommended to keep patients during these situations. They have to check infections, chest X-ray, blood and urine.  

Fatigue

Some patients experience fatigue

Infections and Bleeding

Treatment with azacitidine can increase the risk of infections and bleeding. but this risk is not much higher than for those receiving only supportive care.

Kidney Problems 

Experienced kidney problems are not a common side effect. It is a rare side effect. Especially when azacitidine is taken with other chemotherapy drugs. 

Liver Function Changes

If any patient has liver problems they need close monitoring for blood-related side effects, but usually, no specific dose adjustments are required based on liver function alone. However, caution is advised for those with significantly elevated liver enzymes.

Post-Marketing:

• Reports include hypersensitivity reactions, lung problems, tumor lysis syndrome, Sweet’s syndrome, necrotizing fasciitis, and differentiation syndrome.

Global Availability

Azarest is available for delivery worldwide, including the USA, UK, Saudi Arabia, Dubai, Kuwait, Qatar, Philippines, Nepal, Malaysia, Indonesia, Thailand, Poland, Peru, South Korea, New Zealand, Netherlands, Georgia, France, Egypt, Australia, Germany, Canada, Uzbekistan, Lebanon, Mexico, Singapore, Vietnam.