Osimert 80 MG (Osimertinib moa & Osimertinib Dose)

Description

Osimert 80 mg; Osimertinib moa, Osimertinib Dose, Osimertinib structure &  Side Effects

Indications

Osimert 80 mg is a cancer medication. Its generic name is Osimertinib. Osimert 80 mg is recommended for the patients who are suffering from non-small lung cancer (NSCLC). Doctors prescribed this medication when cancer has spread to other parts of the body and especially for those whose cancer has specific mutations in the EGFR gene. 

These mutations include exon 19 deletions or exon 21 L858R mutations, both of which are commonly found in NSCLC patients. The presence of these mutations must be confirmed through an FDA-approved diagnostic test before treatment with Osimert 80 mg begins. 

Product Feature

Brand Name: Osimert

Active Ingredient: Osimertinib

Manufacturer: Everest Pharma Ltd

Indication: Treats non-small cell lung cancer

Dosage Form: Tablet

Strength: 80 mg

Package Size: 30 Tablets per box

Storage Requirements: Store at 20°C to 25°C

Availability: For export only

Pharmacology 

Osimert 80 mg’s main ingredient is Osimertinib. It belongs to a class of drugs called kinase inhibitors. This medication helps patients to slow down cancer cells. Osimert 80 mg terget specific proteins that help cancer cells to grow and spread in the other body parts.  It specifically targets the epidermal growth factor receptor (EGFR).  EGFR helps to grow many types of cancer cells. 

Osimertinib (Osimert 80 mg)  works by binding irreversibly to certain mutant forms of EGFR, including the T790M, L858R, and exon 19 deletion mutations. These mutations increase the activity of the EGFR, allowing cancer cells to multiply unchecked. 

These mutations make EGFR more active and for this reason cancer cells grow more without any control. Osimertinib  (Osimert 80 mg) helps to block EGFR and slow down the growth of cancer cells and also in some cases, It shrinking the tumors. Osimert 80 mg effectively damages healthy cells of cancer. 

Osimertinib (Osimert 80 mg) is broken down in the body into two active substances, AZ7550 and AZ5104. These can be found in the blood after the drug is taken by mouth. Both substances block EGFR mutations, just like Osimertinib. AZ5104 is even stronger against specific mutations (like exon 19 deletion and T790M) and is about 15 times stronger than Osimertinib in blocking normal EGFR, which helps target harmful mutations while sparing healthy cells.

Osimertinib Dose and Administration

For adults, the recommended dose of Osimert is 80 mg, taken by mouth once a day. Treatment should continue until the cancer gets worse or if the patient has serious side effects that require stopping the drug. Osimert 80 mg can be taken with or without food, making it easy to fit into a daily routine. 

Osimertinib (Osimert 80 mg) recommended 80 mg once in a day for adult patients. Treatment should  continue until the cancer gets worse. If a patient experiences a serious side effect that is required to stop the treatment then the patient has to stop the treatment with the permission of the doctor. 

Missing Dose  Of Osimert 80 Mg

If any patients miss a dose, they have to continue with the next dose in time. Do not double the dose. If a patient has any confusion about timing or anything else, they should contact the doctor. Some patients have difficulty swallowing tablets. They can dispersed Osimert 80 mg in the non-carbonated water.  

Stir the mixture and drink it right away. Rinse the container, and drink the rinse water to make sure you get the full dose. For patients using a nasogastric tube, the same method can be used, with extra water to make sure all of the medicine is given. 

Drug Interactions

Patients can take osimertinib (Osimert 80 mg) with other medication. This is especially true for drugs that affect the cytochrome P450 enzyme system, known as CYP3A. This interaction can be more effective for the treatment and also it can increase the side effects. This enzyme helps break down many medicines. If it is affected, it can change the amount of Osimert 80 mg in the blood.      

Strong CYP3A Inhibitors

Some drugs, like certain antibiotics (such as Telithromycin), antifungals (such as Itraconazole), and antivirals (such as Ritonavir), can block CYP3A. When this happens, it can raise the amount of Osimertinib (Osimert 80 mg) in the blood. This may lead to stronger effects or more side effects. It can cause more side effects. 

Strong CYP3A Inducers

On the other hand, drugs that induce CYP3A, such as Phenytoin, Rifampicin, and St. John’s Wort, can decrease Osimert levels in the blood, potentially reducing its effectiveness. If these drugs must be taken concurrently, the Osimert 80 mg dose may need to be adjusted.

Side Effects

Osimertinib (Osimert 80 mg) treatment can be the cause of several side effects. These side effects can be common or serious. Patients have to be conscious about side effects.  Common side effects are manageable. But patients have to inform their health care provider about the side effects. 

• Diarrhea
• Rash
• Dry skin
• Nail changes 
• Mouth sores
• Fatigue
• Decreased appetite

Pregnancy and Lactation

Osimertinib (Osimert 80 mg) is not recommended for pregnant women. It can cause serious harm to a developing fetus. There is no adequate data on the effects of Osimertinib in pregnant women. Animal studies have shown that osimertinib can be harmful for the development and fetal death. 

Women who can have child, should use effective contraception during treatment. Male patients with female partners who can become pregnant should also use birth control during treatment and for four months after the treatment ends.

It is unknown whether Osimertinib (Osimert 80 mg) passes into human breast milk. Due to the potential for serious adverse effects in nursing infants, breastfeeding is not recommended during treatment with Osimert.

Precautions

Interstitial Lung Disease and Pneumonitis

Osimertinib (Osimert 80 mg) has many side effects. It can be the reason for serious lung disease.If any patient has an issue with lung disease and pneumonitis. It can be life treating for the patients. If any patient found any side effects like cough, trouble breathing, or fever then they should immediately inform the doctor.  The treatment should be stopped if ILD is found. 

QTc Prolongation

Osimertinib (Osimert 80 mg) can make the QTc interval longer. It can be the cause of serious heart problems. If any patient has QTc issues should be carefully monitored by the Doctor. If the QTc interval becomes too long, the drug may need to be stopped or the dose lowered.

Cardiomyopathy

Osimertinib (Osimert 80 mg) has been linked to heart muscle problems in rare cases. Before starting the treatment, patients should check their heart and also check every three months after that. If a patient experiences any issues or major changes in the heart functions then they should inform their doctor immediately. In this condition, Osimertinib may need to be stopped.   

Special Populations 

• Pediatric Use: The safety and effectiveness of Osimertinib (Osimert 80 mg) in children have not been established.  
• Geriatric Use: In study, It was found that Osimertinib 80 mg is equally effective in older patients. There is no difference in how well it works compared to younger patients. Older patients may experience more severe side effects like a higher incidence of Grade 3 and 4 adverse reactions. 

• Renal and Hepatic Impairment: Osimertinib 80 mg can be used in patients with mild to severe renal impairment without dose adjustment. Doctors don’t know how the drug works in people with end-stage kidney disease or severe liver problems. They should use it carefully with these patients.

Storage Conditions

Osimert 80 mg should be stored at temperatures below 30°C and care for don’t touch your children.