Tocit 5 Mg (Tofacitinib) – 60 Tablets

Introduction to Tocit 5 mg

Tocit 5 Mg is a prescription oral tablet that contains Tofacitinib, a targeted synthetic DMARD (tsDMARD) used to treat autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and juvenile idiopathic arthritis. Manufactured by Drug International Limited, Tocit is the affordable generic alternative to Xeljanz (Pfizer’s brand). With proven clinical benefits, Tocit 5 Mg offers patients an effective, accessible, and safe option for managing chronic autoimmune diseases.

 

What is Tocit 5 Mg (Tofacitinib)?

Tocit 5 Mg is an oral tablet containing Tofacitinib, a JAK (Janus kinase) inhibitor used in the treatment of several autoimmune and inflammatory conditions. It works by blocking overactive immune signals that lead to joint pain, swelling, and tissue damage.

 

Tocit belongs to the group of targeted synthetic disease-modifying antirheumatic drugs (tsDMARDs), which means it doesn’t just reduce symptoms but also slows the progression of diseases like rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and juvenile idiopathic arthritis.

 

Developed and marketed by Drug International Limited, Tocit offers an affordable, high-quality alternative to the brand-name drug Xeljanz (Pfizer’s Tofacitinib). Its effectiveness, accessibility, and lower cost make it a popular choice for patients worldwide. Tocit is not only available in 5 mg, it is also available in 11 mg XR.

 

Tocit 5 Mg vs Tocit 11 Mg (Extended-Release)

Feature	Tocit 5 Mg	Tocit 11 Mg XR
Dosage Form	Immediate-release tablet	Extended-release (XR) tablet
Dosing Frequency	Typically taken twice daily	Taken once daily
Onset of Action	Faster absorption, quicker relief	Slower release, maintains stable drug levels
Best For	Patients needing flexible dosing or combination therapy	Patients who prefer once-daily convenience
Conditions Treated	Rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, JIA	Same conditions with long-term control

 

Tocit 5 Mg vs Xeljanz 5 Mg

Feature	Tocit 5 Mg	Xeljanz (Pfizer)
Active Ingredient	Tofacitinib	Tofacitinib
Formulation	5 mg tablets, also available in 11 mg XR	5 mg tablets, 10 mg tablets, 11 mg XR
Manufacturer	Drug International Limited (Bangladesh)	Pfizer (USA)
Drug Class	JAK inhibitor (tsDMARD)	JAK inhibitor (tsDMARD)
FDA Approval	Generic version, meets international standards	FDA-approved originator brand
Indications	RA, PsA, UC, JIA, off-label uses	RA, PsA, UC, JIA
Price	More affordable, cost-effective $ 50 USD in – Unit Pharmacy	Higher cost due to brand pricing $ 4,500 USD in – Unit Pharmacy
Accessibility	Widely available in developing countries	Mostly available in developed countries

 

How Does Tocit 5 Mg Work? (Mechanism of Action)

Janus kinase (JAK) inhibitors explained

Tocit 5 Mg belongs to the JAK inhibitor class of medicines. These drugs block the activity of Janus kinase enzymes, which are key mediators in immune signaling.

 

Role of JAK1 and JAK3 in autoimmune diseases

JAK1 and JAK3 are crucial enzymes involved in cytokine signaling pathways that drive inflammation in arthritis and colitis. Tocit selectively inhibits these enzymes, reducing immune overactivation.

 

Tocit as a targeted synthetic DMARD (tsDMARD)

Unlike nonbiologic DMARDs such as Methotrexate, and unlike biologic DMARDs such as Adalimumab (Humira), Tocit is a tsDMARD — a modern category of oral immunomodulators offering precise action with convenient oral dosing.

 

Difference between Tocit, biologic DMARDs, and nonbiologic DMARDs

• Nonbiologic DMARDs (e.g., Methotrexate): Traditional oral drugs with slower onset.
• Biologic DMARDs (e.g., Humira): Injectables targeting specific cytokines.
• Tocit 5 Mg (tsDMARD): Oral, targeted, faster-acting, and easier for patients to manage.

 

Medical Uses of Tocit 5 Mg (Approved Indications)

Tocit for Rheumatoid Arthritis (RA)

Tocit 5 Mg is approved for treating moderate to severe RA in adults who have not responded adequately to Methotrexate or biologics. It helps reduce joint pain, stiffness, and long-term joint damage.

Tocit for Psoriatic Arthritis (PsA)

In patients with PsA, Tocit reduces joint inflammation and improves skin symptoms when used as monotherapy or in combination therapy with Methotrexate.

Tocit for Ulcerative Colitis (UC)

For adults with moderate to severe UC, Tocit 5 Mg helps control intestinal inflammation, induce remission, and maintain long-term disease control.

Tocit for Juvenile Idiopathic Arthritis (JIA)

Approved for children and adolescents, Tocit provides a non-injectable option for managing polyarticular JIA, improving quality of life for younger patients.

 

Emerging & Off-Label Uses of Tocit

Tocit in Ankylosing Spondylitis (AS)

Clinical studies show Tocit 5 Mg may benefit patients with ankylosing spondylitis, reducing spinal inflammation and stiffness.

Investigational role in Crohn’s Disease

While not yet FDA-approved, Tofacitinib has been studied in Crohn’s disease, with promising results for some patients.

 

Tocit 5 Mg vs Other Treatments

Tocit vs Methotrexate

• Methotrexate: First-line DMARD, slower effect, injectable/oral.
• Tocit 5 Mg: Faster action, oral, effective even when Methotrexate fails.

Tocit vs Baricitinib (Olumiant)

Both are JAK inhibitors, but Tocit targets JAK1/JAK3, while Baricitinib primarily targets JAK1/JAK2.

Tocit vs Upadacitinib (Rinvoq)

Rinvoq is a newer JAK1 selective inhibitor, but Tocit 5 Mg remains widely used due to affordability.

Tocit vs Filgotinib

Both are oral JAK inhibitors, but Filgotinib is less widely available compared to Tocit 5 Mg.

Tocit vs Adalimumab (Humira)

Humira is a biologic DMARD requiring injections. Tocit 5 Mg offers a convenient oral alternative.

Tocit vs Corticosteroids

Steroids are often used short-term, but Tocit provides a long-term disease-modifying approach without steroid side effects.

 

Tocit 5 Mg vs Other Tofacitinib Brands

While Tocit 5 Mg is a trusted and affordable Tofacitinib option, patients often ask how it compares with other generic alternatives available on the market. Below is a clear comparison of Tocit 5 Mg with similar medicines:

Feature	Tocit 5 Mg	Tofacent 5 Mg	Jakura 5 Mg	Tofacinix 5 Mg	Tofaxen 5 Mg
Active Ingredient	Tofacitinib	Tofacitinib	Tofacitinib	Tofacitinib	Tofacitinib
Manufacturer	Drug International Ltd.	Incepta Pharma Ltd.	Beacon Pharma Ltd.	Beacon Pharma Ltd.	Everest Pharma Ltd.
Drug Class	JAK inhibitor (tsDMARD)	JAK inhibitor (tsDMARD)	JAK inhibitor (tsDMARD)	JAK inhibitor (tsDMARD)	JAK inhibitor (tsDMARD)
Dosage Form	5 mg tablet	5 mg tablet	5 mg tablet	5 mg tablet	5 mg tablet
Conditions Treated	RA, PsA, UC, JIA	RA, PsA, UC, JIA	RA, PsA, UC, JIA	RA, PsA, UC, JIA	RA, PsA, UC, JIA
Price Range	$ 50 USD in – Unit Pharmacy	$ 30 USD in – Unit Pharmacy	$ 200 USD in – Unit Pharmacy	$ 65 USD in – Unit Pharmacy	$ 45 USD in – Unit Pharmacy
Key Difference	Known for global supply & trust	Widely used in Bangladesh	Strong oncology & immunology portfolio	Marketed for affordability	Internationally available

• All these medicines (Tocit, Tofacent, Jakura, Tofacinix, Tofaxen) contain the same active ingredient (Tofacitinib) and work in the same way.
• The main differences lie in manufacturers, branding, pricing, and availability.
• Patients can expect similar efficacy and safety regardless of the brand, as long as the drug is genuine and sourced from a trusted pharmacy like Unit Pharmacy.

 

Clinical Trials & Regulatory Approvals of Tocit 5 Mg

Tocit 5 Mg (Tofacitinib) has been extensively studied in multiple clinical trials to evaluate its safety and efficacy for autoimmune diseases such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), ulcerative colitis (UC), and juvenile idiopathic arthritis (JIA).

Condition	Key Clinical Trial Findings	Regulatory Status	Notes
Rheumatoid Arthritis (RA)	Significant reduction in joint pain, swelling, and progression; effective as monotherapy or with Methotrexate	FDA-approved (via Xeljanz reference)	Long-term studies show sustained efficacy and manageable safety profile
Psoriatic Arthritis (PsA)	Improvement in joint function and skin symptoms	FDA-approved (via Xeljanz reference)	Can be used alone or with other DMARDs
Ulcerative Colitis (UC)	Induces and maintains remission in moderate to severe UC	FDA-approved (via Xeljanz reference)	Monitored for infection risk and liver function
Juvenile Idiopathic Arthritis (JIA)	Safe and effective in children/adolescents	FDA-approved (via Xeljanz reference)	Dosing adjusted by weight; requires regular monitoring

 

Tocit 5 Mg Dosage & Administration

Tocit 5 Mg (Tofacitinib) is an oral medication designed to treat autoimmune diseases like rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and juvenile idiopathic arthritis. Proper dosing and administration are crucial for maximizing benefits while minimizing risks.

5 mg Standard Dosage Guidelines

Condition	Recommended Dose	Frequency	Notes
Rheumatoid Arthritis (RA)	5 mg	Twice daily	Can be used as monotherapy or with Methotrexate; monitor liver enzymes and blood counts
Psoriatic Arthritis (PsA)	5 mg	Twice daily	Effective for joint and skin symptoms; may combine with other DMARDs
Ulcerative Colitis (UC)	10 mg	Twice daily (induction phase)	After remission, switch to 5 mg twice daily for maintenance
Juvenile Idiopathic Arthritis (JIA)	Weight-based dosing	Twice daily	Pediatric dosing adjusted per weight; regular monitoring recommended

Extended-Release Option

Feature	Tocit 5 Mg	Tocit 11 Mg XR
Tablet Type	Immediate-release	Extended-release (XR)
Dosing Frequency	Twice daily	Once daily
Onset of Action	Faster absorption, quicker relief	Slower release, maintains stable blood levels
Best For	Flexible dosing or combination therapy	Convenient once-daily dosing for long-term use

Administration Tips

• Take with or without food.
• Do not crush or chew extended-release tablets (Tocit 11 Mg XR).
• Consistent timing is important to maintain steady drug levels.
• Monitor regularly: liver function tests, blood counts, cholesterol, and infection signs.

What You Need to Know

• Tocit 5 Mg offers flexible dosing for adults and children.
• Extended-release 11 Mg tablets provide once-daily convenience.
• Following dosage guidelines and monitoring ensures safe and effective treatment.

 

Safety Profile & Warnings of Tocit 5 Mg

FDA and EMA approval of Tocit

Tocit 5 Mg is an FDA and EMA-approved generic equivalent of Xeljanz, ensuring international safety standards.

Black Box Warning – What Patients Should Know

Tocit carries a black box warning for risks of serious infections, thrombosis, and certain cancers.

Risks of Serious Infections

Patients taking Tocit 5 Mg may face increased risk of TB, pneumonia, shingles, and fungal infections.

Risk of Blood Clots and Thrombosis

Deep vein thrombosis (DVT) and pulmonary embolism (PE) are rare but serious risks associated with Tocit.

Cancer and Malignancy Risks

Long-term use of Tofacitinib may increase the risk of certain cancers, requiring close monitoring.

Liver Enzyme Monitoring & Blood Tests

Patients must undergo liver function tests and CBC monitoring to ensure safe treatment.

Drug Interactions and CYP3A4 metabolism

Tocit is metabolized by CYP3A4 enzymes, meaning interactions with antifungals, antibiotics, and antivirals are possible.

 

Patient Guidance & Practical Considerations

Who should not take Tocit (contraindications)

Patients with active infections, severe liver disease, or high thrombosis risk should avoid Tocit.

Monitoring requirements during treatment

Regular blood counts, liver function tests, and cholesterol checks are mandatory.

Cost and Tocit 5 Mg price comparison

Tocit 5 Mg is significantly more affordable than Xeljanz while offering the same effectiveness.

Tocit 5 Mg online buy – How to purchase safely

Patients can buy Tocit 5 Mg online from trusted pharmacies like Unit Pharmacy, ensuring authenticity and safe delivery.

Affordable Tocit vs Branded Tofacitinib

Switching from Xeljanz to Tocit can reduce treatment costs without compromising outcomes.

Shared decision-making between patient and doctor

Patients should consult their rheumatologist or gastroenterologist before starting Tocit therapy.

 

Frequently Asked Questions (FAQs) About Tocit 5 Mg

Q1: What is Tocit 5 Mg?
A: An oral Tofacitinib tablet for RA, PsA, UC, and JIA to reduce inflammation and pain.

Q2: How do I take Tocit 5 Mg?
A: Usually 5 mg twice daily with or without food. XR 11 mg tablets are once daily.

Q3: Side effects of Tocit 5 Mg?
A: Common: headache, mild infections, nausea. Rare: blood clots, liver issues.

Q4: Can I take it with other medicines?
A: Some drugs (especially CYP3A4-related) may interact. Always consult your doctor.

Q5: Tocit 5 Mg vs other brands?
A: Works like Xeljanz, Tofacent, Jakura, Tofacinix, and Tofaxen. Differences are price and manufacturer.

Q6: Safe for children?
A: Yes, for JIA, with weight-based dosing and monitoring.

Q7: How soon does it work?
A: Some improvement in 2–4 weeks; full effect in up to 3 months.

Q8: Long-term use safe?
A: Yes, with regular monitoring of blood tests, liver function, and infection risk.

Q9: Where to buy safely?
A: Trusted pharmacies like Unit Pharmacy ensure authentic, safe supply.

 

Conclusion

Tocit 5 Mg is a safe, effective, and affordable Tofacitinib option for managing autoimmune conditions like RA, PsA, UC, and JIA. With proven clinical efficacy, flexible dosing options, and a strong safety profile, Tocit provides patients a reliable alternative to branded medications like Xeljanz. Backed by regulatory approvals and extensive trials, Tocit 5 Mg ensures long-term disease control, improved quality of life, and cost-effective treatment. Patients should consult their healthcare provider for personalized dosing and monitoring to achieve optimal results.