Tofaxen 5 Mg (Buy Tofacitinib)
Product Details: Tofaxen 5 Mg (Buy Tofacitinib)
Generic Name: Tofacitinib
Formulation: Tablets
Available Pack Size: 60 tablets per bottle
Available Strengths: 5 mg
Manufacturer: Everest Pharmaceuticals Limited
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Tofaxen 5 mg Price
Price (USD): $45.00
Quantity: 60
Tofaxen 5 Mg (Buy Tofacitinib)
Tofaxen 5 Mg (Buy Tofacitinib) is a Drug, under the name Xeljanz, belonging to a class of medications called Janus kinase (JAK) inhibitors. Its mechanism involves inhibiting the activity of Janus kinase enzymes, which play a role in the inflammatory processes underlying conditions such as rheumatoid arthritis and psoriatic arthritis.
Please read this in details to know about Buy Tofacitinib , Who should not take tofacitinib, Tocit 5 Mg long-term benefits, what is tofacitinib used for.
Each TOFAXEN film-coated tablet contains Tofacitinib Citrate, which is equivalent to 5 mg of Tofacitinib.
How tofacitinib works (Tofaxen 5 Mg)
Tofaxen 5mg (Best option Of Tofacitinib) Tablet is a type of medicine called a Janus kinase inhibitor. Tofaxen 5mg Tablet works by stopping the enzyme Janus kinase from working. This reduces the immune system’s activity and lowers inflammation linked to rheumatic diseases and ulcerative colitis.
Mechanism of Action
Tofacitinib acts as a Janus Kinase (JAK) inhibitor. JAKs are intracellular enzymes that transmit signals from cytokine or growth factor-receptor interactions on the cellular membrane, affecting processes like hematopoiesis and immune cell function.
Tofaxen 5 Mg (Buy Tofacitinib) Uses
Indications and what is tofacitinib used for
Tofaxen is prescribed for adult patients with:
- Moderately to severely active rheumatoid arthritis (RA)
- Psoriatic arthritis (PA)
- Ulcerative colitis (UC)
It is intended for those who have not responded adequately or are intolerant to methotrexate. TOFAXEN can be used alone or with methotrexate or other nonbiologic disease-modifying antirheumatic drugs (DMARDs).
Dosage and Administration
Tofaxen 5 Mg (Best Tofacitinib options)
Administration Guidelines
Do not start TOFAXEN if:
- Absolute lymphocyte count is below 500 cells/mm³
- Absolute neutrophil count (ANC) is below 1000 cells/mm³
- Hemoglobin is below 9 g/dL
Recommended Dosages
Rheumatoid Arthritis and Psoriatic Arthritis (with nonbiologic DMARDs):
- Take Tofaxen 5mg Tablet twice daily, you can take this medicine with food or without food
- For patients with moderate to severe renal impairment or moderate hepatic impairment, the dosage is 5 mg once daily.
Ulcerative Colitis:
- Initial: 10 mg twice daily for 8 weeks
- Maintenance: 5 mg twice daily
- If no adequate response by week 8, extend 10 mg twice daily for an additional 8 weeks, then 5 mg twice daily for maintenance.
- Discontinue if no benefit by week 16.
- For moderate to severe renal or hepatic impairment, reduce the total daily dose by half.
Overdose Management
There is no specific antidote for Tofacitinib overdose. In such cases, monitor the patient for any signs and symptoms of adverse reactions.
Tocit 5 Mg long-term benefits
In Treatment of Rheumatoid arthritis
Tofaxen 5 Mg (Buy Tofacitinib) Tablet will help you to live a normal life by reducing pain, stiffness, Inflammation, so that you can do your daily activities easily. It can help to reduce joint pain, Stiffness, swelling in your joints and block the progression of bone and joint damage. It also helps to reduce inflammation problems.
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Tofacitinib side effects
Common adverse reactions include:
- Upper respiratory tract infection
- Nasopharyngitis
- Diarrhea
- Headache
- Elevated cholesterol levels
- Increased blood creatine phosphokinase
- Rash
- Herpes zoster
Can tofacitinib cause cancer
Drug Interactions
With other medications:
- Tofacitinib exposure increases with potent inhibitors of cytochrome P450 (CYP) 3A4 (e.g., ketoconazole) and CYP2C19 (e.g., fluconazole).
- Not recommended to combine with biologic DMARDs or potent immunosuppressants like azathioprine and cyclosporine.
With food and others:
- Avoid grapefruit juice as it can increase Tofacitinib levels.
Pregnancy and Lactation
Pregnancy Category C:
- No adequate, well-controlled studies in pregnant women.
- Use during pregnancy only if the potential benefit justifies the risk to the fetus.
- It is unknown if Tofacitinib is excreted in human milk, so exercise caution when administered to nursing women.
Safety Advice
- Alcohol
Safe
It’s safe to drink alcohol while taking a Tofaxen 5mg Tablet. No harmful side effects are expected.
- Pregnancy
Consult Your Doctor
Tofaxen is not recommended during pregnancy. While human studies are limited, animal studies have shown it might harm the baby. Your doctor will consider the risks and benefits before prescribing it. Please consult your doctor.
- Breastfeeding
Consult Your Doctor
It’s probably unsafe to take a Tofaxen 5mg Tablet while breastfeeding. There is some evidence that the drug could pass into breast milk and harm the baby.
- Driving
Safe
Taking a Tofexen 5 mg tablet does not create any difficulties in your ability to drive.
- Kidney
Caution
If you have severe kidney disease, use Tofaxen 5mg Tablet with caution. You may need a dose adjustment. Please consult your doctor.
- Liver
Caution
If you have severe liver disease, use Tofaxen 5mg Tablet with caution. You may need a dose adjustment. Please consult your doctor.
What If You Miss a Dose?
If you miss a dose of Tofaxen 5mg Tablet, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time.
Storage Conditions
- Store below 25°C.
- Do not remove desiccant.
- Keep out of reach of children.
Reference: Everest Pharmaceuticals Limited
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