Alecnib 150 Mg (Alectinib) – 56 Capsules

How to Use Alecnib 150 Mg

Alecnib 150 Mg should be used strictly as prescribed by a healthcare professional. It is available in the form of alectinib capsules, which should be taken orally. The generic name of this medication is Alectinib, and it is widely recognized for its efficacy in treating advanced stages of cancer.

1. Timing

Dosage Frequency: Gaining the most benefit from this product with the least side effects, will be taking two doses a day (morning and early evening with food).

Regularity: For certain drugs to sustain constant drug concentration in the body, doses must be entrenched at the same time every day.

2. Dosage Adjustment

Doctor’s Guidance: Change the dose only with your healthcare provider’s guidance.

Missed Dose: If you miss a dose, take it as soon as you remember, unless the next dose is due within 6 hours. In that case, omit the missed dose and continue your normal schedule.

Dose Reduction: Modifications are needed for patients with adverse effects such as hepatic dysfunction or debilitating fatigue.

3.  Precautions

Capsule Integrity: Swallow alectinib capsules whole with water — do not crush, chew or split them, as doing so may affect the drug’s effectiveness.

Dietary Restrictions: Grapefruit or grapefruit juice inhibit CYP3A4 enzyme, increasing the side effects.

Monitoring: May require regular blood tests, liver function tests, and ECGs (known as an electrocardiogram) to check for toxicity or effects.

4.  Missed Dose

If you miss a dose but are less than 6 hours late, take the dose when you remember. If it is more than 6 hours past the dose time, skip the missed dose—do not take 2 doses together.

5.  Overdose Action

Symptoms: Symptoms of alectinib capsules an overdose may include symptoms of severe nausea, vomiting, and liver damage, such as yellowing of the skin or the whites of the eyes.

Emergency Response: In case of overdose, call your health care provider right away or go to the nearest hospital.

6.  Storage

Temperature: Alectinib 20°C to 25°C; excursions permitted between (15°C-30°C) for short periods. It is important to store the medication out of reach of children and pets. Moisture and light can degrade the capsules, so keep them in their original container.

So, it is a way for the patients to take the maximum effect of Alecnib 150 with no risks. Remember whether to buy alectinib always seek personalized recommendations from a healthcare provider.

Indications of Alecnib 150 Mg

Alecnib 150 is indicated for the treatment of patients with ALK-positive non-small cell lung cancer (NSCLC). It is particularly effective in cases where the cancer has spread to other parts of the body or when other treatments have failed.

1.  ALK-Positive Non-Small Lung Cancer (NSCLC)

Indication: Alecnib is indicated for the treatment of ALK-positive NSCLC, which involves a specific type of genetic alteration in the colorectum.

2.  Treatment Stage

Advanced or Metastatic Cancer: This therapy is recommended after 2 other treatments have been attempted, when the cancer is considered advanced, or has started to spread to other organs, such as the brain.

3. First-Line Therapy

To delay disease progression, improve survival, and avoid chemotherapy, it is used as a first-line treatment for ALK-positive NSCLC patients who have just been diagnosed.

4. Post-Crizotinib Therapy

Indicated for patients with metastastic disease that has progressed on or become intolerant of Crizotinib, an earlier-generation ALK inhibitor.

5. CNS Activity

Shows efficacy on both treatment and prevention of the progression of brain metastases — a frequent complication of advanced NSCLC.

6. Precision Medicine

Tailored for individual treatment in accordance with ALK genetic mutations to enable superior results measures than conventional chemotherapy.

Visit your health care provider for more information.

Therapeutic Class

Alecnib belongs to the antineoplastic agents therapeutic class. These drugs are specifically designed to target and inhibit the growth of cancer cells, making them a critical part of cancer treatment protocols.

1. Drug Classification

Alecnib is an antineoplastic agent used as a type of tyrosine kinase inhibitor (TKI).

2. Targeted Therapy

Alecnib is specifically a targeted therapy directed at cancer cells with ALK potential, differentiating it from traditional chemotherapy which damages healthy cells and increases systemic toxicity.

3. Mechanism of Action

It inhibits ALK (anaplastic lymphoma kinase), a receptor tyrosine kinase involved in cancer cell growth and survival, blocking pathways that are important for tumor growth.”

4. Primary Use

Useful for ALK (anaplastic lymphoma kinase) positive non-small cell lung cancer (NSCLC), particularly in metastatic or advanced stages

5. Clinical Advantages

Provides longer PFS, better quality of life, and enhanced efficacy for the treatment of brain metastases compared to first and second generation ALK.

Before starting medication, individuals must undergo thorough medical evaluation by a healthcare provider who will monitor the treatment closely to ensure it’s used safely and effectively.

Pharmacology

Alecnib 150 Mg’s mechanism of action is rooted in its ability to inhibit ALK, a receptor tyrosine kinase.

1. Absorption

When taken with food, alectinib is widely absorbed and its bioavailability is increased, guaranteeing therapeutic drug levels in the body.

Taking it without food greatly lowers absorption.

2. Metabolism

Predominantly liver metabolised to the active metabolite (of efficacy similar to that of the parent drug) of CYP3A4 metaboliser.

Dosage adjustments may be necessary for those with impaired hepatic function.

3. Elimination

The drug and its metabolites are predominantly eliminated in the feces (around 98%), with minimal urinary excretion (less than 1%).

4. Half-Life

The long half-life of Alecnib, about 32.5 hours, enables the maintenance of steady therapeutic levels with twice-daily dosing.

5. Clinical Implications

Relevant hepatic biomarkers: Moderate hepatic metabolism is pertinent to drug clearance; therefore regular liver function tests are paramount.

Strong CYP3A4 inducers or inhibitors may disrupt drug efficacy when multiple drugs are used simultaneously.

Manufacturer: Everest Pharmaceuticals Ltd.

Everest Pharmaceuticals Ltd. a reputable company that manufactures Alecnib 150 Mg (Alectinib) this medicine. With a reputation for compliance with rigorous international manufacturing standards, it guarantees that its products meet the regulatory requirements for safety, efficacy, and quality. Everest Pharmaceuticals manufactures innovative drugs through cutting-edge facilities and technologies that target important therapeutic areas, including oncology.

Everest Pharmaceuticals also focuses on accessibility, offering support programs that help make drugs like Alecnib affordable to eligible patients. Everest Pharmaceuticals has become a trusted name in the pharmaceutical industry by committing to innovation, quality, and affordability.

Dosage of Alecnib 150 Mg

The recommended dose of Alecnib 150 Mg for the treatment of ALK-positive non-small cell lung cancer (NSCLC) is 600 mg orally twice a day (four 150-mg capsules per dose). Alecnib must be taken with food for better absorption of the drug and to keep the drug level optimal. Patients should take as directed on the regiment every 12 hours.

1. Standard Dosage

For ALK-positive non-small cell lung cancer (NSCLC), the recommended dose is 600 mg twice daily, or four 150 mg capsules in each dose.

2. Administration

Administer Alecnib with food to enhance absorption and to reduce gastrointestinal adverse events.

3. Dosage Adjustments

If there are serious side effects (including liver toxicity or interstitial lung disease), a provider may decrease the dose or halt the medication for a period of time.

While on treatment, liver function and ECG monitoring are recommended to assess for any dose-dependent issues.

4. Missed Dose

If you miss a dose, take it as soon as you remember, except when it is time for the next dose (within 6 hours); in this case skip the missed dose. Never take two doses at once.

5. Overdose

For overdose, get medical help immediately. Symptoms of an overdose can include severe nausea, vomiting and liver dysfunction.

6. Adjustments for Special Populations

Patients with severe liver impairment or renal insufficiency, may need to adjust their dosage, because liver and renal impairment can affect drug metabolism and clearance.

7. Duration of Treatment

Alecnib should be continued as long as the patient is having benefit from therapy, the disease is not progressing, and the patient can tolerate the drug. Some patients may stay on treatment for long stretches, and others may have to stop because of side effects or disease resistance.

Routine assessments are necessary for best outcomes.

Interaction of Alecnib 150 Mg

Alecnib may interact with other medications, foods, or supplements, potentially affecting its efficacy or increasing the risk of side effects.

1. Drug Interactions

CYP3A4 Inhibitors: Strong inhibitors of CYP3A4 (including ketoconazole, ritonavir, itraconazole) increased the blood concentrations of Alecnib and therefore increase the risk of side effects including liver toxicity and QT interval prolongation.

CYP3A4 Inducers: rifampin and carbamazepine may reduce Alecnib levels byupregulating its metabolism, which can decrease its anti-tumor efficacy.

2. Food Interactions

Avoid grapefruit and grapefruit juice, which inhibit CYP3A4, causing increased plasma concentration of Alecnib and possible adverse reactions.

Alecnib should be taken with food, to enhance absorption and minimize gastrointestinal side effects.

3. Interactions with Herbs and Supplements

Some herbal supplements (eg, St. John’s Wort) may decrease the activity of Alecnib by CYP3A4 induction. Always tell your doctor about any supplements you are taking.

4. Drugs for Cardiac Arrhythmias

Drugs that influence heart rhythm, including antiarrhythmics or QT-prolonging agents, may increase risk of potentially serious cardiac adverse events when used concurrently with Alecnib.

5. Monitoring

As Alecnib could have potential interactions altering the safety or effectiveness of other drugs it is imperative to follow liver function, kidney function, and ECG regularly with or without other concomitant medications.

Side Effects of Alecnib 150 Mg

Like all medications, Alecnib 150  may cause side effects. While most are manageable, it is crucial to report severe reactions to a healthcare provider immediately.

1. Common Side Effects

Fatigue: which is a common side effect that may decrease energy and cause general weakness, affecting the ability to perform daily tasks,

Gastrointestinal Disturbances: Nausea, vomiting, diarrhea, and constipation are common. These symptoms can usually be alleviated with anti-nausea medications or dietary changes.

Reduced appetite: Some patients may eat less, which can lead to wight loss and malnutrition.

2. Serious Side Effects

Liver toxicity: Increased liver enzymes (AST, ALT), jaundice or more advanced liver damage may take place. Changes should be monitored with regular blood tests measuring liver function.

Interstitial Lung Disease (ILD): This disease can cause significant lung inflammation, and its symptoms include persistent dry cough, fever and shortness of breath. If ILD is suspected, there can be no time to lose; medical assistance ought to be sought immediately.

Cardiac Abnormalities: Alecnib can cause a prolonged QT interval (an imbalance of the electrical activity of the heart), which can cause arrhythmias. An ECG should be monitored fairly regularly to assess heart rhythm.

Edema (Swelling): In some patients, swelling might occur discovered in the legs, feet, or palms, causing discomfort and limited mobility.

3. Less Common Side Effects

Missed, delayed or uncertain periods: Some patients may find a delay in their menstrual cycle due to the medication.

Visual Disturbance: In unusual cases, patients may experience blurred or altered vision.

Rash: There can be skin rashes on the body which can be treated accordingly.

4. Management of Side Effects

Monitor: Liver function, kidney function, and ECG should be monitored regularly.

Symptom Management: For milder symptoms, including nausea or fatigue, medication modifications, dietary changes, or supportive therapies can often provide some relief.

End of Treatment: Alecnib should be stopped if there is a serious side (e.g., ILD, unusual liver damage). Always seek the advice of your health care provider before making any changes.

Patients should always communicate new or strange symptoms to their health care provider so that they can intervene early and manage side effects.

Pregnancy & Lactation

Alecnib 150 Mg is not recommended for use during pregnancy or lactation due to potential harm to the fetus or infant.

1. Pregnancy

It is used for cancer treatment, but its use during pregnancy is not recommended due to the risk of fetal harm. Studies indicate it can harm the fetus, including causing developmental abnormalities. Women of childbearing potential must use effective contraception during treatment and for a predetermined time period after cessation to prevent pregnancy.

2. Lactation

It is unknown whether Alecnib is excreted in breast milk. But since breastfeeding can be harmful to the infant, breastfeeding is not recommended during treatment. If breastfeeding is important, other medications should be used.

3. Precautionary Measures

Women who are planning a pregnancy or pregnant should speak with their health care provider about other forms of the treatment that will not endanger the unborn child.

Drug Classes

Alecnib 150 Mg is a Tyrosine Kinase Inhibitor (TKI) and belongs to a broader group of drugs called targeted therapy. The medications are designed to particular stop or inhibit the volume of particular enzymes that are vital for the growth, division and survival of malignant cells.

1. Mechanism of Action

Alecnib is an inhibitor of ALK (anaplastic lymphoma kinase), a receptor tyrosine kinase that plays a key role in cancer cell growth and proliferation, especially found in patients with ALK-positive NSCLC. Instead, by targeting ALK mutations, Alecnib blocks signalling pathways that promote tumour growth and spread.

2. Specificity and Benefits

TKIs, like Alecnib, are more specific than classic chemotherapy, which target both cancerous and healthy cells. This targeted approach reduces injury to surrounding tissues providing fewer side effects and enhanced quality of life for patients.

3. Additional Mechanisms

Certain TKIs, such as Alecnib, have exhibited a capacity to achieve high concentrations in the CNS due to their capacity to cross the blood-brain barrier, which is not a common characteristic of many chemotherapy agents available on the market, strengthening their therapeutic potential in brain metastases. This represents a major advantage in treating metastatic brain cancers.

4. Categories of Tyrosine Kinase Inhibitors

First-Generation TKIs: These include crizotinib, which acts on ALK and ROS1, but with lower selectivity, leading to possible prolongation of resistance.

Second-Generation TKIs: More selective high-potency drugs (e.g., alecnib, brigatinib), with greater efficacy and lower resistance.

Third-generation TKIs: Newer drugs such as lorlatinib not only target ALK but also target mutations that cause resistance to first- and second-generation TKIs.

5. Combination Therapies

Depending on the patient’s condition and the specific type of cancer, Alecnib and other TKIs are sometimes used in combination with other therapies (e.g., chemotherapy or immunotherapy) for a more comprehensive approach to cancer treatment. A combination of therapeutics may improve efficacy and facilitate the overcoming of resistance mechanisms.

6. Ongoing Research

Beyond NSCLC, the use of TKIs is further extending into other cancers bearing defined genetic mutations. Language: Command (assuming human input)Research on ALK inhibitors such as Alecnib continues, and it is also being investigated for other cancers that involve alterations in the ALK gene, such as certain lymphomas and sarcomas.

The success of Alecnib and other TKIs has transformed the landscape of cancer therapy, providing patients with a more effective and tolerable alternative to traditional treatments.

Mechanism of Action

Alecnib is a selective tyrosine kinase inhibitor with activity against ALK (anaplastic lymphoma kinase), a receptor tyrosine kinase involved in the regulation of several growth factors involved in the pathogenesis of various cancer types. Mutations or fusions in the ALK gene, and particularly in non-small cell lung cancer (NSCLC), result in prolonged activation of the ALK enzyme, which drives excessive cell division and tumor upsurge.

1. Targeting ALK: Alecnib binds to the ALK enzyme and blocks its activity which negates the downstream signaling pathways that would cause cell division and result in cancer proliferation.

2. Tumor Inhibition: Through its actions, Alecnib inhibits fully the growth of ALK-positive tumor cells resulting in tumor inhibition and reduced risk for metastasis.

3. Specificity: it is targeted and damages normal healthy cells less, leading to fewer side effects compared with classical chemotherapy.

Overdose Effects

Too much Alecnib 150 Mg can cause dangerous and serious demands on the body and require immediate emergency care. Alecnib possesses a narrow therapeutic index (the difference between the therapeutic and overdose dose is minimal), thus an increase in the dosage of the drug could lead to a significant increase in toxicity.

1. Symptoms of Overdose

Gastrointestinal Distress: An overdose can result in severe nausea and vomiting, often catapulting the downward spiral of dehydration and hypokalemia (potassium loss).

Liver Damage: Liver toxicity may increase and present with signs of liver damage like yellowish skin (called jaundice), dark colored urine or elevated liver function tests (such as high AST, ALT). In severe cases, it can result in liver failure.

Cardiac Effects: Overdose with alecnib can cause QT interval prolongation, which can lead to dysrhythmias such as ventricular tachycardia or torsades de pointes, which can be fatal if not treated quickly.

Severe Fatigue and Weakness: An overdose can lead to the increased general fatigue, dizziness, and weakness that may interfere with everyday functioning and increase the chance of falling or sustaining an injury.

2. Management and prompt action

Mechanism: Depending upon the amount of drug ingested, patients may require observation in the hospital and hydration as well as other supportive measures. Blood tests will be carried out to determine liver function, electrolyte levels and heart rhythm.

Symptomatic Treatment: No specific antidote for Alecnib overdose exists, and management is mainly concerned with symptomatic and supportive care, including antiemetics for nausea, and hydration with intravenous fluids. ECG monitoring is important to recognize and treat any cardiac arrhythmias in a timely manner.

Dose Adjustment or Discontinuation: Alecnib may need to be stopped in the event of an overdose, and the dose should be adjusted when the patient stabilizes.

3. Prevention

Patients must always take the exact dose prescribed, and never self-adjust the medication. Regular monitoring by medical providers (e.g. liver function tests, ECGs, blood tests) can help prevent accidental overdose as well as detect early signs of toxicity.

When patients and caregivers understand the implications of sticking to the prescribed regimen, they are less likely to miss a dose, lowering the risk of an accidental overdose.

4. Prognosis

The effect of an overdose can vary depending on the time of medical help and the severity of symptoms. If addressed in a timely manner, the majority of symptoms can be treated, and the prognosis is usually good. But serious overdoses with prolonged liver injury or cardiovascular events can result in more dire complications or even death.

It is important to seek medical help immediately if overdose symptoms develop or overdose is suspected to ensure the best chance of recovery for the patient.

Uses of Alecnib 150 Mg

Alecnib 150 Mg Indications The drug is mainly used to treat a type of non-small cell lung cancer (NSCLC), which is positive for the anaplastic lymphoma kinase (ALK) gene mutation or the ALK gene fusion that causes abnormally high growth of cancer cells.

First Line Treatment: It is generally recommended to patients with advanced or metastatic ALK+ NSCLC if the patient has never received ALK targeted therapy. Alecnib has been shown to shrink tumors and prolong survival.

Treatment After Other Therapies: After other ALK inhibitors have not worked (such as crizotinib): Alecnib may be an option for patients due to its ability to target the range of mutations.

Brain Metastases: Because Alecnib penetrates the blood-brain barrier, it is particularly beneficial in treating NSCLC with brain metastases.

By targeting specific cells, alecnib can have fewer adverse effects, which can make it a preferable treatment for some patients.

Storage Conditions

Alecnib 150 Mg Keep at room temperature between 20°C to 25°C (68°F to 77°F). Leave the medication in its original packaging for protection from light and moisture. Do not put the capsules in bathrooms or moist spots. Keep out of the reach of children and pets to avoid accidental ingestion. Proper storage preserves the drug’s potency and helps ensure its safety up to its expiration date.

Why Choose Alecnib 150 Mg?

Alecnib 150 Mg is a highly effective, targeted therapy for ALK-positive non-small cell lung cancer (NSCLC) patients that has several advantages over traditional treatments.

1. Mechanism of action: Alecnib selectively targets ALK, the mutated driver of cancer cell growth in ALK-positive NSCLC, and functions as a potent inhibitor of tumor growth, with limited effects on normal cells and significantly fewer side effects relative to chemotherapy.

2. Efficacy: Effective: Clinical trials demonstrate that Alecnib significantly increases progression-free survival in patients with small cell lung cancer, and it can cross the blood-brain barrier and therefore is more effective in patients with variant lung cancer tabled with fine cell lung cancer.

3. More Tolerability: Alecnib has much better side effect profile than old ALK inhibitors which offers a more tolerable treatment for the patients.

4. Convenient Dosing: Alecnib is given orally twice daily and with food, which can facilitate ease of use for patients. Such benefits make Alecnib one of the patients’ preference for advanced ALK-positive NSCLC treatment.

Alternative Medicine for Alecnib (Alectinib) 150 Mg

Alecinix 150 Mg (Generic Alectinib) is one of the alternative medications to Alecnib 150 Mg. Alecinix has the same active ingredient and works the same way, aiming to treat ALK-positive non-small cell lung cancer (NSCLC) patients. Similar to Alecnib, it blocks that ALK protein, halting the growth and spread of cancer cells. Similar efficacy and safety of Alecinix makes this drug a promising option for patients who require alternative treatment in the management of advanced or metastatic ALK-positive NSCLC. Always consult with your healthcare provider first before switching medications, so you can ensure proper dosing and appropriateness depending on your individual health conditions.

Alectinib Price and Accessibility

Alectinib (Alecnib) costs may differ based on where you live and whether you use a brand or generic, but in general the 150 mg dose costs around. In many breaks, the brand-name version is hugely more expensive than generic alternatives such as Alecinix. Prices can top over $1,000 or so a month without insurance. Out-of-pocket expenses may be reduced through patient assistance programs and insurance plans. For the latest pricing and current discounts, contact a healthcare provider or pharmacist. Some online pharmacies might be able to provide cheaper prices if patients qualify.

Patient Review

Last year I was also diagnosed with ALK positive NSCLC and my oncologist prescribed me with 150 Mg of Alecnib. At first I was scared of the side effects, but the treatment has been life-changing. I’ve had very little in the way of side effects, mild fatigue, which I can handle. My scans have revealed months of decreasing tumor size and my quality of life has gone way up. I have more energy and hope. Alecnib has really helped me in my battle against cancer, and I’m thankful for this treatment.

FAQ

1. What is Alecnib 150 Mg used for?

Alecnib 150 Mg is used to treat ALK-positive non-small cell lung cancer (NSCLC), which is a type of lung cancer that tests positive for abnormalities in the anaplastic lymphoma kinase (ALK) gene.

2. How should I take Alecnib 150 Mg?

Alecnib is administered orally twice daily with food. Take the capsules whole and do not crush or chew. Do not change the dose unless your healthcare provider tells you to.

3. What are the side effects of Alecnib?

The most common side effects include fatigue, nausea, diarrhea and constipation. Severe side effects, such as liver dysfunction and heart rhythm abnormalities, can also happen.

4. Is it safe to use Alecnib in pregnancy?

Alecnib are not recommended during pregnancy because it can harm the fetus. It is recommended to use effective contraception during treatment.

5. What if I forget to take Alecnib?

If you miss a dose, get it as soon as you remember, unless it’s nearly time for your next dose. Never take two doses at once.

6. What should I avoid while taking Alecnib?

Do not take these with grapefruit or grapefruit juice; they can inhibit the metabolism of the medication. Also, cautious with CYP3A4 inhibitors or inducers.

7. How much does Alecnib cost?

The cost of Alecnib may vary according to location, brand and coverage. If you have not been prescribed a specific medication, you could try generic versions, such as “Alecinix”, that tend to be more cost efficient.

Disclaimer

The information provided is intended for educational and informational purposes only and should not be regarded as medical advice or a replacement for consulting with a licensed healthcare professional. Always consult your doctor or pharmacist before starting, stopping, or changing the dosage of Alecnib 150 Mg (Alectinib). If you are taking this medication, you should follow strict medical instructions.