Caboxen 20 Mg (Cabozantinib) – 90 Capsules

Caboxen 20 MG Generic Cabozantinib is a cancer medication that prevents the growth of cancer cells in the body. Caboxen 20 MG belongs to the class of drugs known as tyrosine kinase inhibitors (TKIs) that slow or stop the growth of cancer cells. This guide will provide basic information you require about Caboxen 20 MG including the uses, dosage instructions, side effect, interactions, etc.

How to Use Caboxen 20 MG

Here is a more in-depth explanation on how to use Caboxen 20 MG effectively:

Dosage:

– Brand Name: 60 mg (3 capsules of 20 mg): The standard adult starting dose is 60 mg once a day. But your healthcare provider might make some changes to the dose depending on the diagnosis, response to the treatment and side effects you might be experiencing.

– Follow Instructions: It is important to consume it as directed. Never change your dose without your doctor’s guidance, even if you think it’s too much or too little.

With or Without Food:

– Administering Flexibility: Caboxen can be administered either with or without food. But it does need to be taken consistently the same every time. This aids with absorption and reduces digestive irritation.

– Impact 2: To reduce stomach upsets, you can take it along with food whenever possible, especially if you feel nauseous.

Swallow Whole:

– Avoid Crushing or Chewing: Swallow the Caboxen 20 MG capsules as a whole. Capsules should not be crushed or chewed, because crushing or chewing can release the drug too early and make it less effective.

– Safety: Capsules that are broken or chewed can release a higher concentration of the active ingredient in the body, possibly leading to a greater risk of side effects.

Water:

– Filling up on Water: Always consume the capsule with a full glass of water (at minimum 8 oz). This allows the capsule to dissolve properly, so you can swallow it without too much trouble on your part.

– Hydration: You should keep your water intake at safe levels during your overall treatment plan, since hydration can help avoid some side effects from your medicines, like dehydration — particularly if you develop diarrhea.

Missed Dose:

– Missed Dose: If you miss a dose, take it as soon as you remember, unless it is almost time for the next dose. If so, skip the missed dose and go back to your regular timetable.

– Don’t Double Dose: Never take 2 doses at the same time to compensate for a missed dose. This could raise the risk of serious side effects, including potentially leading to overdose. If you’re uncertain, always check with your doctor for advice.

Avoid Alcohol:

– Loosen Up: Alcohol can potentiate some of the side effects like liver toxicity that can reduce the effectiveness of Caboxen.

– Health hazards: Consuming alcohol during Caboxen can also exacerbate some of the other side effects such as dizziness, nausea, or fatigue. I recommend abstaining entirely or cutting way back on alcohol during treatment.

Monitoring:

– Routine Medical Assessments: Your physician may have you take routine blood tests while you are in treatment, especially during treatment to assess how the liver, kidneys, and blood pressure are functioning.

– Blood Pressure Monitoring: Medications like Caboxen can occasionally lead to elevated blood pressure, requiring routine monitoring of blood pressure. Tell your health care provider right away if you have headaches, dizziness, or blurred vision.

– Liver Function: Cabozantinib may cause liver problems. Your doctor will also periodically run liver function tests to make sure your liver is handling the medication well.

Other Important Considerations:

– Stick to a Schedule: Try to take Caboxen at roughly the same time every day for optimal results. Establishing a routine will help minimize missed doses, which will help ensure more consistent therapeutic effects.

– Traveling: If you are traveling, carry the prescribed quantity of Caboxen 20 MG with you. Bring it in its original packaging so as not to confuse it and make sure you can follow the prescribed schedule for taking them.

If you follow these guidelines, you will be able to use Caboxen 20 MG safely and effectively, which can increase its chances to treat your condition while reducing side effects. Remember to always communicate with your doctors anytime you have an inquiry or issue pertaining to the treatment.

Indications of Caboxen 20 MG

Caboxen 20 MG (cabozantinib) is mainly used to treat the following types of advanced or metastatic cancer: Here’s a review of what it is indicated for:

Renal Cell Carcinoma (RCC):

– Main Use: Caboxen is used (as a cancer treatment) in advanced or metastatic kidney cancer (called renal cell carcinoma) with anticancer effect in patients whose kidney cancer cannot be removed surgically, or who do not respond to other treatments.

– Why Use It: RCC cells tend to make excess amounts of specific proteins that support tumor growth. It works because these proteins, when blocked, slow tumor growth.

Medullary Thyroid Cancer (MTC):

– Primary Use: For medullary thyroid cancer that spread (metastatic) or is unable to be surgically removed.

– Why Use It: MTC cells are frequently driven by aberrant growth signals. Caboxen works by targeting these signals to slow or stop cancer growth.

Hepatocellular Carcinoma (HCC):

– Primary Indication: For advanced liver cancer (HCC) not responding to surgery or other standard treatments.

– Why Use It: Caboxen blocks the growth factors responsible for blood vessel development that promote tumor growth and metastasis, allowing it to control liver cancer growth.

Criteria for Use:

– Advanced Stage: Caboxen is generally used for advanced, metastatic, or inoperable cancer.

– When Other Treatments Have Failed: Usually considered after chemotherapy or targeted therapies have not had enough effect.

Caboxen is an essential treatment option for challenging cancers not responding to traditional therapies.

Therapeutic Class

Cabozantinib (Caboxen 20 MG) — a type of tyrosine kinase inhibitor (TKI) medication. Here’s a look at what this means and how it can help patients:

Tyrosine Kinase Inhibitory Protocols (TKI):

– Targets Action: TKIs, such as Caboxen, target the specific tyrosine kinases, abnormal proteins that are responsible for the development, growth, proliferation and spreading of cancer cells. These enzymes play a key role in tumor growth and their inhibition is beneficial for controlling cancer progression.

Multi-Targeted Therapy:

– VEGFR/c-Met: Caboxen blocks the vascular endothelial growth factor receptor (VEGFR) and c-Met, the receptors mediating blood vessel formation (angiogenesis) and cancer metastasis. This starves tumors of the oxygen and nutrients they require.

Anti-Angiogenesis:

– Impedes Angiogenesis: Caboxen starves the tumor by blocking the growth of new blood vessels (angiogenesis) needed for tumor growth.

Benefits for Patients:

– Slows Cancer Growth: Caboxen delays or stops cancer cells from growing by inhibiting various signaling pathways leading to better survival rates for patients suffering from late-stage kidney, liver and thyroid cancers.

TKI drugs are important in the therapeutic category of drugs that provide a targeted, more targeted form of treatment for cancer that can be instrumental in controlling aggressive or metastatic cancers.

Pharmacology

Caboxen 20 MG (cabozantinib) is a targeted therapy with the following pharmacological properties:

Active Ingredient:

Active chinof Caboxen 20 MG is cabozantinib, a tyrosine kinase inhibitor (TKI).

Mechanism of Action:

– VEGFR Inhibition: Angiogenesis supply O2 and nutrition food for tumor.

– c-MET inhibition: crossing pathways used by the cancer cells for growth, migration, and metastasis.

– AXL and RET Blockade: Targets other receptors contributing to aggressive cancer behaviors, making the drug effective against resistant tumors.

How the body absorbs and makes use of it:

Well absorbed via oral routes, with maximal plasma concentrations achieved within 2–5 h.

Whether or not you take the medication with food doesn’t significantly affect absorption, but being consistent is important.

Metabolism:

Metabolized in the liver (most notably by enzyme CYP3A4), making it vital to avoid drugs that would inhibit this enzyme.

Excretion:

Effective systemic clearance was shown with approximately 54% of the drug excreted in feces and 27% in urine.

Therapeutic Focus:

Indicated for advanced kidney (RCC), liver (HCC), and thyroid (MTC) cancers by disrupting pathways and important cancer propagation 3[5].

Caboxen’s multi-target pharmacology yields a therapeutic versatility that influences drug selection in the treatment of resistant and advanced cancers.

Manufacturer: Everest Pharmaceuticals Ltd.

Everest Pharmaceuticals Ltd. the manufacturer for delivering high-end oncology products using modern manufacturing processes. Here’s how they produce and verify quality:

Production of Active Pharmaceutical Ingredients (APIs):

– Its active ingredient, cabozantinib, is produced with high standards of purity to conform to therapeutic effectiveness.

Capsule Formulation:

– Using advanced technology, the company is able to produce uniform, bioavailable capsules with precise dosing for patients.

Quality Assurance:

– They certify that their product is pure, stable, and effective by following Good Manufacturing Practices (GMP) during their manufacturing process and performing stringent testing during the manufacturing process.

Regulatory Compliance:

– Products are manufactured in accordance with international guidelines put in place by regulatory bodies like the FDA and WHO.

Focus on Patient Safety:

– To ensure the product maintains its integrity under different conditions, stability studies are conducted and advanced packaging methods are employed.

Everest Pharmaceuticals Ltd. develops reliable and quality cancer medicines such as Caboxen 20 MG by following these principles and ensuring safety for the world of patients.

Dosage of Caboxen 20 MG

Caboxen 20 MG: 1 capsule (20 mg) once daily, then as needed according to response and side effects. In certain cases, a higher starting dose of 60 mg (3 capsules) might be prescribed. Doses are adjusted if side effects show up, or if either kidney or liver function is impaired. Liver and kidney function should be monitored regularly, and dose reduced accordingly if any abnormalities are found.

– Standard Dosage:

The recommended dosage for Caboxen 20 MG is 1 capsule (20 mg) once daily. This can be increased based on your doctor’s advice and how you feel in response to treatment.

– Dosage Adjustments:

Starting Dose: Most patients begin at 60 mg a day (three 20 mg capsules), although your doctor may reduce this due to side effects.

Side Effects Adjustments: If you experience severe side effects (such as severely high blood pressure or liver toxicity), your doctor may reduce the dose, or stop the treatment temporarily until the side effects resolve.

– Consideration for Kidney Function:

Renal Function: Dosages may be adjusted in patients with impaired renal function. Your doctor will regularly monitor your kidney function.

– Liver Function Monitoring:

Caboxen can also impact liver enzymes and regular liver function tests are advised. Dose adjustment or discontinuation may be required for liver abnormalities.

– Missed Dose:

If you forget to take a dose, take it as soon as you remember, unless it is close to your next dose. Never double-dose.

– Controlling for Other Drugs:

Tell your doctor all of the medicines you take because they may interact with Caboxen and require dose adjustments. Ensure that you are taking Caboxen 20 MG for as long as your doctor prescribes it.

Interaction of Caboxen 20 MG

Caboxen 20 MG can interact with other drugs, which can change how well they work or cause serious side effects. Drugs that can interact with Caboxen 20 MG are:

CYP3A4 Inhibitors:

– Potential Risk: Reduced elimination of Caboxen by drugs that inhibit CYP3A4 (e.g., ketoconazole, itraconazole, grapefruit) can lead to increased blood levels of Caboxen and thus, increased side effects, including liver toxicity or hypertension.

If any CYP3A4 inhibitors are prescribed to you, your physician may decrease your Caboxen dosage or increase your monitoring.

CYP3A4 Inducers:

– Potential risk: CYP3A4-inducing drugs (eg, rifampin, phenytoin, or St. John’s Wort) can decrease the effect of Caboxen by decreasing the concentration in the blood.

– Action: If you are taking powerful CYP3A4 inducers, your doctor may have to raise your Caboxen dose or switch to a different treatment.

Other Cancer Treatments:

– Chemotherapy and Immunotherapy: Co-administration of Caboxen with chemotherapy, immunotherapy, or other tyrosine kinase inhibitors may increase side effects such as severe fatigue, gastrointestinal toxicity, and liver dysfunction.

– What to do: Always make sure your oncologist knows all the other medications you take, to prevent dangerous interactions and to help them plan your treatment effectively.

– Uses of Caboxen 20 MG: Interactions of Caboxen 20 MG: It is highly recommended to consult with a doctor or lifelong expert for dose validation and adjustments when you are taking Caboxen 20 MG with other drugs.

Side Effects of Caboxen 20 MG

Caboxen 20 MG may have some side effects like fatigue, diarrhea, nausea and lack of appetite. Severe reactions can involve liver toxicity, high blood pressure, bleeding and heart issues. For safe use, however, you will need to have your side effects monitored regularly and reported immediately to your doctor.

– Common Side Effects:

Fatigue: Feeling abnormally tired is a common side effect. Taking breaks and modifying your activities can help manage this.

Diarrhea: Commonly have with Caboxen. Staying hydrated and taking anti-diarrheal medication can relieve symptoms.

Nausea and Vomiting: Few patients can have problems in gastrointestinal iron absorption. Taking the medication with food or with anti-nausea medication may help.

Loss of Appetite: A loss of appetite may develop. Also helpful is eating smaller, more frequent meals.

– Serious Side Effects:

Liver Toxicity – May cause elevated liver enzymes which can lead to liver damage. Frequent liver function tests are required.

Express these numbers in order of blood pressure (hypertension)

Bleeding: This can include nosebleeds, gum bleeding, or spontaneous (internal) bleeding. Get medical help if any bleeding is unusual.

Heart Issues: Some individuals may suffer from problems with the heart, such as heart failure or unexplained heart arrythmias.

– Rare but Severe Reactions:

Perforation: Gastric perforations are a serious but rare risk.

Thyroid Dysfunction: Thyroid function may rarely be altered and should be monitored.

Make sure to follow up with your doctor if any side effects occur so they can be properly managed and adjusted.

Pregnancy & Lactation

Caboxen 20 MG must not be taken during pregnancy as it can harm the fetus; it is a category D drug. It is also unsafe for nursing mothers, as the medication can transfer into breast milk, where it can impact the infant. Ask your doctor about alternatives.

– Pregnancy:

Pregnancy Category: Caboxen is category D. It can cause harm to the fetus. It can lead to birth defects or other major harm to the fetus.

Recommendation: Pregnant women and women who plan to become pregnant should not use Caboxen. You should talk with your doctor about any potential risks if you’re pregnant.

– Lactation (Breastfeeding):

Infant Risk: Not recommended during breastfeeding Its passing into breast milk is not known, but because of its potential for serious side effects, it may harm the nursing infant.

Recommendation: Women should not breastfeed while taking Caboxen. If treatment with Caboxen is required, it may be advisable to stop breastfeeding.

– Precaution:

Do not get pregnant: You and your partner must use effective contraceptives while taking Caboxen and for some time after you stop taking the medicine.

RECOMMENDATION: Consult always with your doctor about alternatives if you are pregnant or breastfeeding before starting Caboxen.

Ensuring safety for both the mother and baby should always come first.

Drug Classes

Caboxen 20 MG (cabozantinib) is classified as a tyrosine kinase inhibitor (TKI). These drugs inhibit certain enzymes called tyrosine kinases, which are involved in the growth and dissemination of cancer cells. Caboxen inhibits the activity of several enzymes involved in the tumor growth, angiogenic and metastatic processes which maintain the Tumor Microenvironment (TME) promoting tumor production and proliferation.

– Tyrosine Kinase Inhibitors (TKIs):

Caboxen 20 MG belongs to the class of drugs known as tyrosine kinase inhibitors (TKIs), which inhibit tyrosine kinases, enzymes that play a crucial role in the signal transduction pathways involved in the growth, survival, and proliferation of cancer cells.

– Multi-Targeted Therapy:

Caboxen is multi-targeted, and unlike single-target TKIs, it inhibits multiple key tyrosine kinases that promote cancer progression.

– Key Targets:

VEGFR (Vascular Endothelial Growth Factor Receptor): Inhibits new blood vessels from forming, restricting the supply of nutrients to the tumor

c-Met: Inhibits migration, metastasis and proliferation of tumor cells.

AXL and RET: These receptors promote the metastasis of tumors, which are uhindered by Caboxen.

– Efficacy Against Cancers:

Caboxen is a potent treatment for advanced kidney (RCC), liver (HCC), and thyroid (MTC) cancers with action against multiple pathways involved in cancer cell survival and proliferation.

– Broad Mechanism:

Caboxen works by targeting the key proteins and pathways associated with tumor growth and progression, which can lead to significant reductions or complete halting of tumor proliferation, and can serve as essential treatment alternatives for advanced cancers with poor response to conventional therapies.

That’s what makes Caboxen a powerful drug for aggressive and advanced cancers through its multi-pronged approach.

Mechanism of Action

Caboxen 20 MG (cabozantinib) is a multi-targeted tyrosine kinase inhibitor that targets several important pathways involved in cancer progression. Here’s how it functions:

– Inhibition of VEGFR (Vascular Endothelial Growth Factor Receptor):

Caboxen is an anti-angiogenic that acts by blocking VEGFR. Without blood vessels, tumors become starved of oxygen and nutrients, which makes their growth slow.

– c-Met Inhibition:

It also blocks c-Met, a receptor that increases tumor growth, spread and resistance to other types of treatments. Suppression of c-Met inhibits proliferation and metastasis of cancer cells.

– AXL and RET Receptor Inhibitors:

Caboxen also inhibits AXL and RET, which are all important for tumor survival and metastasis, thus preventing the expansion of cancer.

– Comprehensive Targeting:

Caboxen targets multiple anti-cancer pathways simultaneously, allowing for a broad and powerful anti-cancer effect, especially in kidney, liver, and thyroid cancers.

This multi-targeted approach helps counter advanced-stage and aggressive cancers.

Overdose Effects

Caboxen 20 MG (cabozantinib) overdose symptoms: Cabozantinib overdose symptoms can cause severe side effects by interrupting important biological pathways. Some possible overdose effects may be:

– Severe Gastric Symptoms:

These symptoms can be made worse, causing dehydration and electrolyte imbalances.

– Cardiovascular Issues:

Overdose can trigger a very high heart rate and high blood pressure (hypertension), which raises the risk of heart problems.

– Liver Damage:

Elevated liver enzymes due to hepatotoxicity or hepatocellular injury secondary to cabozatinib overdose.

– Bleeding Risk:

Cabozantinib targets inhibits pathways that convey signals involved in blood clotting, including VEGFR and c-Met, and there can be excessive bleeding or bruising.

– Kidney Dysfunction:

Especially when using high-dose therapy, renal impairment may develop affecting the renal functional capacity.

In the case of suspected overdose, prompt medical treatment is essential for the management of symptoms and supportive care. Follow prescribed dosages to avoid the risks.

Uses of Caboxen 20 MG

Caboxen 20 MG (cabozantinib) is indicated for multiple forms of advanced malignancies. Here’s a closer look at its uses:

– Renal Cell Carcinoma (RCC):

Caboxen treats advanced kidney cancer, including metastatic kidney cancer, where the cancer has spread beyond the kidney. Its mode of action is based on inhibition of the aforementioned VEGFR and c-Met receptors that are key in tumor growth, blood vessels formation and metastasis. Caboxen inhibits these pathways, preventing further spread, minimizing tumor size, increasing survival rates, and offering an alternative when other therapy has been unsuccessful.

– Hepatocellular Carcinoma (HCC):

Caboxen works for patients with advanced liver cancer, especially when the cancer is not resectable or has progressed after previous treatments. Caboxen inhibits VEGFR and c-Met, preventing new blood vessel formation (angiogenesis) and starving the tumor of nutrients, thereby blocking tumor growth and spread.

– Medullary Thyroid Carcinoma (MTC):

Caboxen is used for the treatment of advanced or recurrent medullary thyroid cancer following treatment with other agents. This cancer frequently contains mutations in the RET proto-oncogene, and Caboxen acts by inhibiting RET signal paths that promote the division and metastasis of cancer cells.

– Other Cancers:

However, Caboxen is used off-label for other cancers like non-small cell lung cancer (NSCLC) and neuroendocrine tumors, although its primary oncology indications were RCC, HCC and MTC. The drug’s inhibition of tyrosine kinases including AXL and RET permits its use against a greater variety of solid tumors compared to prior therapies.

Caboxen 20 MG is a multi-targeted agent, which means it holds the potential to target several oncogenic pathways at once, providing a comprehensive clinical activity for patients with advanced and aggressive cancers.

Storage Conditions

Caboxen 20 MG requires storage in a cool and dry environment, away from sunlight and moisture to ensure its potency. It is recommended to store the BIGEYE between 20°C to 25°C (68°F to 77°F); however, short excursions between 15°C to 30°C are allowed. Store the medication in its original package, in order to protect it from light and prevent it from being exposed to moisture. Store away from children as it can lead to accidental consumption Do not use the medicine after the expiration date.

Why Choose Caboxen 20 MG?

Caboxen 20 MG (cabozantinib) is an oral chemotherapeutic agent used for the treatment of various advanced, metastatic cancers including (but not limited to) kidney cancer, liver cancer, and thyroid cancer. Its multi-targeted mechanism acts on important pathways such as VEGFR and c-Met to inhibit tumor growth and metastasis. Caboxen has a broad, more effective mechanism of action compared to other treatments that target a specific receptor responsible for cancer progression. Its capability to target difficult, advanced-stage cancers and slow tumor progression makes it a crucial option for those patients who may not have responded to other treatments.

Alternative Medicine for Caboxen (Cabozantinib) 20 MG

Caboxen 20 MG (cabozantinib) is not ideal for everyone, so other cabozantinib equivalent combinations can be considered to manage progressed cancers. These alternatives include:

– Cabanib 20 MG:

A generic version of cabozantinib, used to treat kidney, liver, and thyroid cancer.

– Caboxen 80 MG:

Caboxen higher dose (for patients needing a stronger treatment approach or during advanced stage cancer treatment)

– Cabozanix 80 MG:

An additional formulation with the same active ingredient, offering more options to patients with a greater dosage need.

– Cabozanix 20 MG & 60 MG:

These allow for individualized treatment for cancer patients through the ability to adjust dosage as needed.

These alternatives inhibit the same cancer-driving pathways and can be considered in light of your doctor’s recommendations and dosing needs. +Always speak with your health care provider before making any changes to your medications.

Cabozantinib Price and Accessibility

The cost of Cabozentinib varies by location, pharmacy, and insurance coverage, so it’s best to check with your local pharmacy for pricing information. Cabozentinib may cost anywhere from $10,000 to $12,000 a month (without insurance). Still, its generic substitutes, Cabanib and Cabozanix, potentially provide cheaper options, lowering costs for patients. This can also vary based on your country or region, where a government assistance program or health insurance might help cover the costs. Patients should speak with their healthcare providers or pharmacists to see if they can find affordable access options or discount programs.

Patient Review

Caboxen 20 MG has seen numerous positive improvements in patients taking it for advanced cancers like kidney and thyroid cancer. They have said that the drug delayed tumor growth and, in some cases, shrunk tumors. But the most common side effects, including fatigue, diarrhea and nausea, are often noted, and some patients require dose adjustments or additional treatments to address symptoms.

Yet even with these challenges, many speak of the drug’s effectiveness in curtailing cancer growth, especially in cases where other treatments have failed. Monitoring liver and kidney function regularly is also emphasised by patients, as Caboxen can affect these organs. In summary, most patients are still happy to be on Caboxen in their fight against cancer, but managing side effects is integral to the process.

FAQ

1. What is Caboxen 20 MG used for?

Caboxen 20 MG (cabozantinib) is made use of to treat advanced cancers around the body, including renal cell carcinoma (kidney cancer), hepatocellular carcinoma (liver cancer), and medullary thyroid cancer. It works by blocking several pathways that drive tumor growth and dissemination.

2. How should I take Caboxen 20 MG?

Caboxen 20 MG should be taken once a day preferably at the same time every day. This medicine may be taken with or without food. Do NOT crush or chew the capsule. If you missed a dose, take it as soon as you remember, but never take two doses at once.

3. What are the common side effects of Caboxen 20 MG?

Nausea, diarrhea, a loss of appetite and fatigue are common side effects. More serious effects may include high blood pressure or liver toxicity, which requires regular monitoring in these patients.

4. Is Caboxen 20 MG safe to be taken during pregnancy or breastfeeding?

Caboxen produce potential harmful effects. Caboxen must never be consumed or used during pregnancy because it may harm the fetus. It is not advised during breastfeeding either, as it can transfer to breast milk.

5. What is the price of Caboxen 20 MG?

Caboxen 20 MG can cost between $10,000 and $12,000 per month without insurance coverage. Cheaper versions may be available, such as Cabanib or Cabozanix.

6.Are there any drug interactions with Caboxen 20 MG?

Caboxen may also interact with CYP3A4 inhibitors (e.g., ketoconazole) and CYP3A4 inducers (e.g., rifampin) and other cancer therapy. Always tell your doctor about any other medications you are taking to prevent dangerous interactions.

Disclaimer

The information provided is intended for educational and informational purposes only and should not be regarded as medical advice or a replacement for consulting with a licensed healthcare professional. Always consult your doctor or pharmacist before starting, stopping, or changing the dosage of Caboxen 20 Mg. If you are taking this medication, you should follow strict medical instructions.