Cabozanix 80 Mg (Cabozantinib) – 30 Capsules

How to Use Cabozanix 80 Mg

Cabozanix 80 Mg have to make sure follow the dosage and instructions provided to you by your healthcare provider when using Cabozanix 80 Mg. The medication generally comes in capsule form and (ideally) is taken by mouth, with or without food. So the capsules should be swallowed whole, without breaking, chewing, or crushing them so that the drug will work properly.

1. Form and Administration:

Cabozanix 80 Mg is a capsule-form oral agent.

2. Dosage Instructions:

The usual dosage for adults is 60 mg taken once daily and can be adjusted according to the patient’s condition and reaction to the treatment. Capsules should be swallowed whole; do not chew, crush or break them.

3. With or Without Food:

Cabozanix 80 Mg can be consumed with or without food. But taking it with food may minimize gastrointestinal discomfort.

4. Missed Dose:

If you forget a dose and it’s less than 12 hours late, take it right away. If more than 12 hours have passed, do not take the missed dose and continue taking it as per schedule.

5. Consistency:

To achieve the best effect, take Cabozanix 80 Mg at the same time every day.

6. Consult Your Doctor:

Always follow your healthcare provider’s specific instructions.

Indications of Cabozanix 80 Mg

Cabozanix 80 Mg is primarily indicated for the treatment of advanced cancers where other therapies have been ineffective. The drug is highly beneficial in the management of:

1. Renal Cell Carcinoma (RCC):

Cabozanix 80 Mg is mainly indicated for the treatment of advanced kidney cancer (RCC) which has spread or is not responsive to other therapies.

2. Metastatic Thyroid Cancer:

It is also indicated for the treatment of metastatic thyroid cancer, particularly in patients with iodine-refractory disease (where iodine therapy is no longer effective).

3. Stage 4B (or 4): Progressive or Advanced Cancer:

Cabozanix 80 Mg Cavogen: It is the first choice to be used when no other options are available, therefore this anti-cancer medication cavalcade offers an additional therapeutic approach to progressive or advanced stage neoplasm.

4. Targeted Therapy:

Cabozanix, as a tyrosine kinase inhibitor, targets tumor-promoting pathways that aid in tumor growth and metastasis.

5. Improved Survival Rates:

These have been associated with an increased progression-free survival and improved overall survival in patients with advanced RCC and thyroid cancer.

Therapeutic Class

Cabozanix 80 Mg is Tyrosine Kinase Inhibitors (TKIs) class of drugs. These drugs block the activity of enzymes called tyrosine kinases that are among the steps that enable cancer cells to grow and divide uncontrollably. Cabozanix does this by inhibiting specific enzymes involved in cancer progression, leading to a reduction in the growth of tumors, particularly for RCC and metastatic thyroid cancer.

1. Tyrosine Kinase Inhibitor (TKI):

Cabozanix 80 Mg is classified as a tyrosine kinase inhibitor (TKI), a type of drug that inhibits certain enzymes (kinases) that play a crucial role in the proliferation and viability of cancer cells.

2. Targeted Cancer Therapy:

As a targeted therapy, Cabozanix acts as a TKI, specifically preventing relevant signal cascades leading to cancer cell proliferation as well as tumor growth.

3. Anti-Angiogenesis Agent:

Cabozanix further suppresses angiogenesis, the process by which tumors form new blood vessels that nourish their development and expansion. By preventing this process, Cabozanix limits the tumor’s ability to receive nutrients and oxygen.

4. Multi-Targeted Action:

Cabozanix, unlike some other TKIs, targets several kinases such as VEGFR, MET, AXL and RET, implicated in different steps during cancer progression and metastasis.

5. Oncology Therapeutic Class:

It is a well-known drug used in oncological medicine for advanced and metastasized cancers enemies like renal cell carcinoma and metastatic thyroid carcinoma.

Pharmacology

Cabozanix 80 Mg (cabozantinib) works by targeting various tyrosine kinases that are key players in the progression of cancer. It inhibits vascular endothelial growth factor receptors (VEGFR), MET, AXL, and RET, which are proteins involved in blood vessel formation, tumor cell survival, and metastasis.

1. Mechanism of Action:

Cabozanix 80 Mg (cabozantinib) blocks multiple tyrosine kinases that play a role in cancer progression, including VEGFR, MET, AXL, and RET. This action inhibits tumor blood supply, growth, and metastasis.

2. VEGFR Inhibition:

Cabozanix works by blocking the receptors of vascular endothelial growth factor (VEGFR), which in turn prevents angiogenesis (new blood vessel formation), starving the tumors of the oxygen and nutrients necessary for their growth.

3. MET and AXL Inhibition:

MET and AXL play key roles in cancer cell survival, proliferation and migration. Cabozanix works to inhibit these kinases so it can reduce tumor spread and treatment resistance.

4. Absorption and Distribution:

Cabozanix 80 Mg is rapidly absorbed, achieving peak plasma levels 3-5 hours after enteral administration.

5. Metabolism and Elimination:

It is mainly metabolized by the liver through cytochrome P450 isoforms, primarily CYP3A4, and has an elimination half-life of 55 hours, permitting once-daily dosing.

6. Excretion:

The drug is mostly eliminated in feces (~70%), whereas a minor fraction is found in urine.

Manufacturer: Beacon Pharmaceuticals Ltd.

Beacon Pharmaceuticals Ltd. is a known pharmaceutical brand of Bangladesh, local and overseas, which produces a wide range of medicines with good quality and in affordable price. With a strong focus on oncology, the company is known for providing effective treatments, such as Cabozanix 80 Mg (cabozantinib), for metastatic thyroid cancer and advanced cancers like renal cell carcinoma. With its focus on research and development, Beacon Pharmaceuticals leads the way of developing innovative products that meet the highest levels of efficacy.

Emphasizing quality, the organization complies with worldwide standards and continuously works toward enhancing patient care. Today, the company exports its products to various Asian, African and other countries and is considered one of the most trusted names in global healthcare. Ensuring that all medications manufactured by the company are safe, reliable, and consistent, the company operates under Good Manufacturing Practices (GMP).

Dosage of Cabozanix 80 Mg

Cabozanix 80 Mg is prescribed according to the condition and response of the patient. Below is a general guideline:

1. Recommended Starting Dose:

Cabozanix 80 Mg (cabozantinib) is a medication used for the treatment of renal cell carcinoma and thyroid cancer that has spread/metastatic cancer, and its standard starting dosage for adults is 60 mg daily.

2. Administration:

Cabozanix 80 Mg will be taken through capsules by mouth. The capsules should be swallowed whole — do not chew, crush or break.

3. Adjusting the Dose:

The dose can be increased according to each patient’s treatment response and tolerability. If side effects are intense, a dose of 40 mg or 20 mg per day may serve.

4. Missed Dose:

If you forget to take a dose, do it as soon as you can, but no more than 12 hours. If you remember more than 12 hours after your scheduled dose, do not take the missed dose, and do not take an extra dose; just take your next dose when you are meant to.

5. Maximum Dose:

For patients that can handle full dosage without substantial side effects, the upper range of the recommended dose is 80 mg per day.

6. Consistency:

Dosage and timing: Cabozanix 80 Mg should be taken at the same time every day to ensure optimal effectiveness of the drug, as it works best when steady levels are maintained in the body.

Interaction of Cabozanix 80 Mg

Cabozanix 80 Mg can respond with a few different medications, which can alter how well it works or raise the chance of symptoms. Drugs that reduce the effect of Cabozanix include:

1. CYP3A4 Inhibitors:

CYP3A4 inhibitors with strong activity (ketoconazole, ritonaVIR) can affect the concentration of Cabozanix 80 Mg in the blood, leading to an increased possibility of side effects such as fatigue, diarrhea, and liver toxicity.

2. CYP3A4 Inducers:

CYP3A4 inducers (e.g., rifampin, carbamazepine) may reduce blood levels of Cabozanix, reducing its effectiveness, and potentially negating its cancer-fighting action.

3. Anticoagulants:

Cabozanix may also increase the risk of bleeding when combined with drugs that affect blood coagulation (e.g., warfarin, dabigatran). When used in combination, regular blood clotting parameters monitoring is advised.

4. Other Tyrosine Kinase Inhibitors:

Co-administration with other tyrosine kinase inhibitors (for example, sunitinib, pazopanib, etc. leads to heightened toxicity (closely monitor).

5. Overall Medication Review:

Preventing Drug Interactions Ask other healthcare providers about all medications you currently take, including over-the-counter medications and supplements.

Side Effects of Cabozanix 80 Mg

Like any medication, Cabozanix 80 Mg can cause side effects, although not everyone will experience them. Some common side effects include:

1. Common Side Effects:

• Fatigue — Patients often feel tired, which can impact their daily routines.
• Diarrhea: This is a common side effect, and it is important to manage hydration.
• Reduced Appetite: Loss of appetite can lead to reduced food intake and essential nutrients.

2. Serious Side Effects:

• Liver Toxicity: Yellowing of the skin or the whites of the eyes, or dark urine or abdominal pain may be signs of liver problems and should be reported to a doctor right away.
• Hypertension (High Blood Pressure)–Blood Pressure should be regularly monitored as Cabozanix reduces Blood Pressure.

3. Hand-Foot Syndrome:

The palms of the hands and the soles of the feet may become red, swollen and/or painful, which can affect mobility and comfort.

4. Bleeding:

Read also: There is an increased risk of internal bleeding, which may present as unusual bruising or bleeding from the gums.

5. Severe Gastro-Intestinal troubles:

Very rarely, there can be a perforation of the gastrointestinal which is life threatening.

Always tell your doctor about any observed side effects so that your treatment plan may be modified if required.

Pregnancy & Lactation

Cabozanix 80 Mg is unsafe to use during pregnancy. It is listed as pregnancy category D, meaning it can harm an unborn child. Cabozanix should not be used during pregnancy or if a patient plans to become pregnant.

– Pregnancy Category:

Pregnancy Category D for cabozantinib (Cabozanix 80 Mg) This means there is proof that it could harm a developing fetus. As a result, it should only be used during pregnancy when the potential benefits outweigh the risks, and then only under the supervision of a health care provider.

– Fetal Risks:

Cabozanix may harm the fetus, causing birth defects and miscarriage. If you are pregnant, you should not take this medication unless absolutely necessary.

– Contraception During the Treatment:

Women of childbearing potential must use highly effective contraception during treatment with Cabozanix and for at least 4 months after stopping the treatment to avoid pregnancy.

– Lactation:

Cabozanix is not recommended in lactation. It can also pass into breast milk and may affect a nursing infant. This medication should not be taken whilst breastfeeding.

– Consult Healthcare Provider:

Education representing the literature is contemporary and maternal treatment is necessary in the case of pregnant or breastfeeding women.

Drug Classes

As mentioned earlier, Cabozanix 80 Mg belongs to the tyrosine kinase inhibitor (TKI) class of drugs. Other examples of TKIs are imatinib (Gleevec) and erlotinib (Tarceva) which are used for different kinds of cancer. These drugs are effective at binding to and targeting proteins that promote cancer cell growth, thereby stopping or slowing the development of certain cancers.

1. Tyrosine Kinase Inhibitors (TKIs):

Cabozanix 80 Mg is a tyrosine kinase inhibitor (TKI), and it works by preventing certain enzymes (kinases) from being activated in the growth and proliferation of cancer cells.

2. Targeted Cancer Therapy:

Cabozanix is a TKI that targets specific molecules that through a cellular pathway are responsible for the survival of cancer cells and proliferation. This allows it to be more precise in targeting cancer than conventional chemotherapy.

3. Anti-Angiogenesis Agent:

Cabozanix is also an anti-angiogeneis agent, so, it prevents the formation of new blood (angiogenesis) vessels that the tumors need to extend and enter other organs.

4. Oncology Medication:

Cabozanix 80 Mg is an oncology medication used primarily in the treatment of renal cell carcinoma and metastatic thyroid cancer.

5. Multi-Targeted Therapy:

Cabozanib not only inhibits BMS-929068, like other single-target TKIs but also inhibits several other receptors (VEGFR, MET, AXL, and RET) and is therefore called multi-targeted therapy for advanced cancers.

Mechanism of Action

Cabozanix 80 Mg works by blocking certain proteins that are found in the cells of cancer tumours. It targets kinases such as:

1. Inhibition of Tyrosine Kinases:

Cabozanix 80 Mg (cabozantinib) is an oral multi-kinase inhibitor targeting tyrosine kinases involved in the signaling pathways regulating the growth, survival, and dissemination of cancer cells.

2. Targeting VEGFR:

A major target is the vascular endothelial growth factor receptor (VEGFR) which is instrumental in angiogenesis (the development of new blood vessels) Cabozanix fights this. It prevents the tumor from developing the blood vessels that it needs to grow by blocking a known receptor for them, VEGFR.

3. MET and AXL Inhibition:

Cabozanix also blocks MET and AXL which play a key role in the proliferation, migration and survival of tumor cells. This process helps inhibit the spread of cancer to other organ systems in the body.

4. RET Receptor Blockade:

Cabozanix also inhibits the RET receptor, another player in various cancers, notably thyroid, and hampers the pathways that lead to cancer progression.

5. Multi-Target Effect:

Cabozanix is a multi-targeted therapy signaling effect by blocking these multiple receptors, effectiveness is achieved in advanced and metastatic cancers.

Overdose Effects

Cabozanix 80 Mg Overdose (oversupply) may lead to severe health complications. Signs of overdose may include severe hypertension, gastrointestinal bleeding, and damage to vital organs.

1. Severe Toxicity Risk:

An overdose of Cabozanix 80 Mg (cabozantinib) can cause a dangerous level of the drug to accumulate in the body, and it can exceed the body’s ability to process it. This can lead to significant side effects, including amplified symptoms normally seen during normal dosing.

2. Gastrointestinal Distress:

Overdose can cause extreme nausea, vomiting, diarrhea and stomach cramps. Coming down with these signs can be worse than normal, and can result in dehydration, electrolyte imbalance, and possible gastrointestinal bleeding, if untreated.

3. Liver Dysfunction:

Hepatotoxicity (or liver toxicity) is one of the more concerning effects of an overdose. Symptoms include jaundice (yellowing of the skin or eyes), dark urine and elevated liver enzymes. Liver failure can happen, necessitating immediate action, such as stopping the medication and possibly being hospitalized.

4. Hypertension (which is also known as High Blood Pressure):

Cabozanix may increase blood pressure, and an overdose can exacerbate this condition. If untreated quickly, severe hypertension can cause heart attack, stroke or kidney damage.

5. Increased Risk of Bleeding:

In the event of an overdose, bleeding complications (e.g., nosebleeds, bruising, or internal bleeding) may be exaggerated, resulting in more serious hemorrhagic events. Patients need to be observed carefully for evidence of too much bleeding.

6. Kidney and Organ Complications

Overdose can also worsen problems with the kidneys, possibly causing an acute kidney injury or failure. Renal function must be monitored closely in overdose situation.

7. Fatigue and Weakness:

As the drug acts more than usual on multiple bodily systems, overdosing on Cabozanix 80 Mg can result in extreme fatigue, dizziness, and a general feeling of weakness.

8. Management of Overdose:

If trying to overdosing, you must contact with medical assistance.” Providers generally will be supportive in nature, monitoring vitals and treating complications as they occur. In extreme situations, patients may need to be hospitalized for aggressive treatment and observation.

Strict adherence to prescribed dosing schedules accordingly prevents these chances of overdose and in case any unusual symptoms are manifested during days of treatment, please contact the health care provider.

Uses of Cabozanix 80 Mg

Cabozanix 80 Mg primarily used for advanced type of kidney cancer (renal cell carcinoma (RCC) ) and advanced thyroid cancer with metastasis. However, research is underway to determine its potential for other cancers, such as liver cancer and other solid tumors.

1. Renal Cell Carcinoma (RCC):

• Cabozanix 80 Mg (cabozantinib) is mainly used to help treat advanced renal cell carcinoma (RCC), a form of kidney cancer. It is for patients with previously treated, unresectable RCC.

2. Metastatic Thyroid Cancer:

• It is also used to treat metastatic thyroid cancer, especially when it is iodine-refractory (when cancer does not take up iodo-active treatment anymore). Cabozanix reduces the progression of the disease and increases survivorship.

3. Tumor Control by a Multi-Targeted Action:

• Cabozanix 80 Mg is a multi-targeted tyrosine kinase inhibitor that specifically hampers growth factor receptors such as the vascular endothelial growth factor receptor (VEGFR), MET, AXL, and RET, involved in the growth of malignant cells and the spread of the tumor. Hence, it is specific to arrest tumor progression.

4. Metastatic Cancer Treatment:

• It is especially effective for the treatment of advanced, metastatic cancers where the cancer has spread to other areas of the body and is a vital option for patients with few treatment alternatives.

5. Improved Survival Outcomes:

• Cabozanix has been studied in clinical trials and demonstrated to improve progression-free survival and overall survival in patients with advanced cancers while maintaining a better quality of life for patients in the late-stage of treatment.

6. Second-Line Treatment Option:

• Cabozanix 80 Mg is also a key second-line treatment for patients who have not benefited from other treatments and a new hope to prolong life and to control cancer more effectively.

Why Choose Cabozanix 80 Mg?

Cabozanix 80 Mg offers several advantages over other cancer treatments:

1. Effectiveness:

Cabozanix 80 Mg is a medication that has been found to be effective in the treatment of advanced renal cell carcinoma and metastatic thyroid cancer. Targeting several critical pathways in cancer progression helps prevent tumor development and extends survival in patients.

2. Convenient Dosing:

Cabozanix’s once-daily dosing schedule provides a convenient option for patients, simplifying the treatment plan and improving compliance. This reduces the number of hospital visits and eliminates complex methods of administration, thus increasing compliance.

3. Proven Safety:

Clinical studies have not established that Cabozanix 80 Mg has a well-known safety profile and manageable side effects. Although some side effects such as fatigue and diarrhea can occur, these are usually temporary and reversible if doses are adjusted.

4. Targeted Therapy:

Cabozanix is a multi-targeted tyrosine kinase inhibitor, meaning that it specifically targets cancer cells and spares healthy tissue from damage, unlike traditional chemotherapy.

5. Improved Quality of Life:

The key benefit of Cabozanix is prolonged life expectancy characterized by progression-free survival, which means patients receiving therapy enjoy increased relative quality of life during the course of the treatment.

Alternative Medicine for Cabozanix (Cabozantinib) 80 Mg

Cabozanix 80 Mg (cabozantinib), there are a number of formulations and doses available as alternatives. These alternatives have equivalent physiologic benefits, in addition to variations in administration and presentation to accommodate a variety of therapy phases. Alternative medicine is 1. Cabanib 20 mg 2. Caboxen 20 mg 3. Caboxen 80 mg 4. Cabozanix 20 mg 5. cabozanix 60 mg. 

1. Cabanib 20 Mg:

Taking Cabanal 20 Mg is a lower-dose bottle of its successor cabozantinib, which is best suited for patients who require dose adjustments owing to side effects or those who are newly commencing their treatment. It is used to treat progressive cancers, including renal cell carcinoma and thyroid cancer, as a slow-release, continuous treatment.

2. Caboxen 20 Mg:

Another alternative is Caboxen 20 Mg, which contains the same 20 mg dose of cabozantinib active ingredient. It’s most often used alongside other treatments or for patients with less advanced disease stages.

3. Caboxen 80 Mg:

80 Mg is also a similar, higher-dose variant to Cabozanix 80 Mg with a stronger effective dose for controlling advanced cancers in patients who are known to require a stronger dose for these purposes. It provides an alternative brand for individuals seeking a similar product while still providing the same therapeutic effects.

4. Cabozanix 20 Mg:

This formulation provides a low-dose option of Cabozanix, which may be particularly useful for patients who require a more tailored treatment approach. Cabozanix 20 Mg is very helpful in dose titration or in patients who have varying tolerance to cabozantinib.

5. Cabozanix 60 Mg:

Cabozanix 60 mg is an intermediate dose option between the 20 mg and 80 mg versions. Prescribing this dose will allow for the effective management of cancer treatment with a fewer incidences of side effects for those patients who require a balanced approach.

Alternative options allow for more flexibility and may be changed according to how the individual responds to treatment, their prior medical history, and the stage of cancer. Always discuss with your healthcare provider which option is right for your treatment plan, as your needs may vary.

 Cabozanix Price and Accessibility

Cabozanix 80 Mg is a value-for-money treatment for renal cell carcinoma as well as metastatic medicine thyroid. The cost of the treatment depends on the country, doctor, and health insurance. Cheaper alternative options such as Caboxen and Cabanib have the same active ingredient but at a lower cost —making the drug an easier option to get. The medication is sold at oncology pharmacies and big drugstores — though availability may differ.

Patient Review

I’m six months into a new job and I’m sitting here on my couch trying to figure out how the hell I get through this when I was first diagnosed with renal cell carcinoma about a year ago and I was blindsided. After attempting several unsuccessful treatments, my oncologist recommended Cabozanix 80 Mg.

I had never heard of this but after doing research I was hopeful. The initial weeks were grueling with adverse effects such as fatigue and nausea, but started getting better eventually. Within a couple of months, my tumor started shrinking. I was more energetic and had my appetite back.” It’s not an easy climb, but Cabozanix has really helped me fight back and have hope for a better tomorrow.

FAQ

1. What is Cabozanix 80 Mg? 

It is used to treat advanced renal cell carcinoma (kidney cancer) and metastatic thyroid cancer.

2. How is Cabozanix 80 Mg taken?

Take it once a day, with or without food, at the same time each day. Swallow the capsule whole.

3. What are the common side effects of Cabozanix?

Frequent side effects include fatigue, diarrhea, appetite loss and high blood pressure.

4. Is it safe to use Cabozanix during Pregnancy?

No, as it is not advisable during pregnancy and while the patient is breastfeeding due to possible harm to the baby.

5. What should I do if I miss a dose of Cabozanix?

Take it as soon as you remember, unless it is almost time for your next dose. Never take two doses at once.

6. Can Cabozanix be taken with other medications?

It can interact with some medications, so tell your doctor about all the drugs you take.

7. How long do I have to take Cabozanix 80 Mg?

How long that is depends on how well you respond to treatment and your doctor’s recommendations. Regular monitoring is necessary.

Disclaimer

The information provided is intended for educational and informational purposes only and should not be regarded as medical advice or a replacement for consulting with a licensed healthcare professional. Always consult your doctor or pharmacist before starting, stopping, or changing the dosage of Tagrix 80 mg. If you are taking this medication, you should follow strict medical instructions.