Palbonix 100 Mg (Palbociclib) – 21 Capsules

How to Use Palbonix 100 MG

Palbonix 100 mg is a prescription medication specifically designed to treat adults with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer. It is used in combination with an aromatase inhibitor as the first hormonal-based therapy or with fulvestrant for those who have experienced disease progression following hormonal therapy.

To ensure optimal effectiveness, Palbonix 100 mg should be taken exactly as prescribed by your healthcare provider. Typically, it is administered orally, with food, once daily for 21 consecutive days, followed by a 7-day break. This 28-day cycle allows the body to recover and minimizes potential side effects. Regular monitoring of blood cell counts and other health parameters is essential throughout the treatment period. 

Indications of Palbonix 100 mg

Palbonix is primarily indicated for the treatment of HR+ and HER2- advanced or metastatic breast cancer. It is particularly effective in cases where:

• It is the first-line hormonal-based therapy for advanced cancer.
• The patient has previously undergone hormonal therapy and experienced progression.

The active ingredient, palbociclib, works synergistically with aromatase inhibitors or fulvestrant to inhibit cancer cell growth and proliferation, offering a targeted approach to managing this aggressive form of breast cancer.

Therapeutic Class

Palbonix belongs to the class of cyclin-dependent kinase (CDK) 4/6 inhibitors. These are specialized cancer therapies that block the activity of CDK4 and CDK6, crucial proteins involved in the cell cycle. By targeting these proteins, Palbonix helps control the rapid division and multiplication of cancer cells. Get All these Medicines and the cost is extremely affordable in UnitPharmacy.

Pharmacology

The pharmacological action of Palbonix lies in its ability to selectively inhibit CDK4 and CDK6. These kinases regulate the transition from the G1 phase to the S phase of the cell cycle, a critical step for cell division. HR+ breast cancer cells depend heavily on CDK4/6 for growth. By halting their activity, palbociclib, induces cell cycle arrest, effectively slowing down or stopping tumor progression. Manufacturer Company: Beacon Pharmaceuticals Ltd.

Dosage of Palbonix 100 mg

The standard dosage of Palbonix 100 mg is one tablet taken once daily for 21 days, followed by a 7-day rest period. This constitutes a complete 28-day cycle. Dosage adjustments may be necessary based on:

• The patient’s tolerance.
• White blood cell count levels.
• Other side effects experienced during treatment.

Always consult your healthcare provider before making any changes to the dosage regimen.

Administration of Palbonix 100 mg

Palbonix tablets should be swallowed whole, with food, and at approximately the same time each day. Crushing, chewing, or breaking the tablets is not recommended as it may affect the drug’s efficacy. If a dose is missed, it should not be doubled to compensate. Patients are advised to continue with the next scheduled dose.

Interaction of Palbonix 100 mg

Palbonix 100 mg can interact with various medications, potentially altering its effectiveness or increasing the risk of side effects. Key interactions include:

• CYP3A inhibitors: Drugs like ketoconazole can increase palbociclib levels, raising the risk of side effects.
• CYP3A inducers: Medications such as rifampin may decrease palbociclib efficacy.
• Anticoagulants and other drugs: Close monitoring is required when combining Palbonix 100 mg with anticoagulants or other therapies.

Patients should provide a full list of medications and supplements to their healthcare provider before starting treatment. How it works?

Side Effects of Palbonix 100 mg

While Palbonix is highly effective, it may cause side effects. Common side effects include:

• Neutropenia: Low white blood cell counts, which can increase infection risk.
• Fatigue and weakness.
• Nausea and vomiting.
• Diarrhea or constipation.
• Hair thinning or loss.

Severe side effects may include:

• Lung problems (pneumonitis): Symptoms like chest pain, cough, and trouble breathing.
• Serious infections due to low neutrophil counts.

If any serious symptoms arise, seek medical attention without delay.

Pregnancy & Lactation

Palbonix 100 mg is contraindicated during pregnancy due to its potential to harm the developing fetus. Women of childbearing age should use effective contraception during treatment and for at least 3 weeks after the final dose. Breastfeeding is not recommended while on Palbonix, as it is unknown if the drug passes into breast milk and could harm the infant.

Drug Classes

Palbonix is classified under targeted cancer therapies, specifically CDK4/6 inhibitors. These therapies offer precision treatment by targeting specific pathways critical to cancer cell survival and growth.

Mechanism of Action

The mechanism of action of Palbonix involves blocking the CDK4 and CDK6 proteins. These kinases drive the cell cycle’s progression, allowing cancer cells to divide uncontrollably. By inhibiting these proteins, Palbonix induces cell cycle arrest in HR+ cancer cells, slowing tumor growth and enhancing the efficacy of hormonal therapies.

Overdose Effects

In cases of overdose, patients may experience exacerbated side effects, including severe neutropenia or gastrointestinal symptoms. Immediate medical attention is required. Treatment typically involves supportive care and monitoring of vital functions.

Uses of Palbonix 100 mg

Palbonix 100 mg is primarily used for the treatment of advanced HR+ HER2- breast cancer. By combining with hormonal therapies, it provides a comprehensive approach to managing metastatic cancer. Additional benefits include slowing disease progression and enhancing the quality of life for patients. 

Alternative Medicine of Palbonix 100 mg

If you’re seeking alternatives to Palbonix 100 mg, consider the following options:

1. Palbonix 125 mg: A higher-dose alternative offering the same mechanism of action in inhibiting CDK4/6 to slow cancer cell growth.
2. Palbocent 125 mg: Another effective option with a similar dosage, targeting the same pathways to treat advanced or metastatic HR+ HER2- breast cancer.
3. Palboxen 125 mg: This alternative also works by blocking CDK4/6, helping manage the progression of HR+ HER2- breast cancer.

These alternatives provide reliable treatment options for patients who may benefit from different formulations or dosing while maintaining the effectiveness in combination with hormonal therapies. Always consult your healthcare provider to determine the most appropriate choice. Get All these Palbociclib Medicines and the cost is extremely affordable in UnitPharmacy.

Storage Conditions

Palbonix 100 mg tablets should be stored in their original packaging at room temperature (15°C to 30°C), away from moisture and direct sunlight. Keep the medication out of reach of children and pets.

FAQ

1. What is Palbonix 100 mg used for?

Palbonix 100 mg is used to treat hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer in adults. It is used in combination with hormonal therapies like aromatase inhibitors or fulvestrant.

2. How does Palbonix 100 mg work?

Palbonix contains palbociclib, which inhibits cyclin-dependent kinases 4 and 6 (CDK4/6). By blocking these proteins, it halts the cell cycle, preventing cancer cells from dividing and multiplying.

3. How should I take Palbonix 100 mg?

Palbonix should be taken orally with food, once daily for 21 consecutive days, followed by a 7-day break. Always follow your healthcare provider\u2019s instructions regarding dosage and administration.

4. What are the common side effects of Palbonix 100 mg?

Common side effects include low white blood cell counts (neutropenia), fatigue, nausea, diarrhea, and hair thinning. Severe side effects, like lung inflammation (pneumonitis), may also occur.

5. Can I take Palbonix 100 mg during pregnancy or breastfeeding?

No, Palbonix is not recommended for use during pregnancy or breastfeeding, as it could harm the developing fetus or infant. Women should use reliable contraception while undergoing treatment and for at least three weeks after the final dose.

6. What should I do if I miss a dose of Palbonix 100 mg?

If you miss a dose, do not double the next dose to compensate. Simply take the next scheduled dose as usual. Inform your healthcare provider about missed doses for guidance.

7. Can Palbonix 100 mg interact with other medications?

Yes, Palbonix can interact with medications such as CYP3A inhibitors (e.g., ketoconazole) and inducers (e.g., rifampin). These interactions may alter the drug\u2019s effectiveness or increase side effects. Inform your doctor about all medications you\u2019re taking.

8. What are the storage conditions for Palbonix 100 mg?

Palbonix should be stored in its original packaging at room temperature (15\u00b0C to 30\u00b0C), away from moisture, heat, and direct sunlight. Keep it out of reach of children.

Disclaimer :

The information provided here is for educational and informational purposes only. It should not be considered medical advice or a substitute for consultation with a licensed healthcare provider. Always consult your doctor or pharmacist before starting, stopping, or changing the dosage of Palbonix 100 mg. This medication should be used under strict medical supervision. UnitPharmacy!